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About us

Founded in 2015, the Advanced Innovation Center for Structural Biology of Tsinghua University is now headed by the distinguished structural biologist, Prof. Yigong Shi.
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Overview Organization
Faculty

Faculty

The Center is home to China’s top structural biology research teams, featuring CAS academicians, and winners of the National Science Fund for Distinguished Young Scholars. Meanwhile, it has trained many postdoctoral fellows and doctoral students as a cradle of outstanding young researchers for domestic and foreign universities and institutes. The Center has an international academic committee consisting of more than ten foreign experts in structural biology, including several Nobel laureates.
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Principal Investigator CO-PI Directors of Core Facilities Advanced Innovation Young Scientist Advanced Innovation Fellow Senior Technician International Academic Advisors
Research

Research

With a focus on structural biology, the Center is developing multidisciplinary strengths in integrating the best practices in method development, fundamental research and translation of research advances, in a bid to deliver some of the original findings with significant influence in the history of science and bolster the biotechnological and biopharmaceutical activities in Beijing.
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Research Field Achievements Supports
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News&Events

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Meeting

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International Conferences Advanced Innovation Lecture Series for Structural Biology Advanced Innovation Workshops for Structural Biology Others
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Scientific research support

Research Field Achievements Supports

Cryo-EM Facility

A world class cryo-electron microscopy (Cryo-EM) facility is the foundation of Tsinghua University Branch of China National Center for Protein Sciences(Beijing). Cryo-EM facility of Tsinghua University provides expertise a nd resources for understanding both molecular a nd cellular structures by using cryo-EM and three-dimensional reconstruction tech nique. The facility has 8 tra nsmission electron microscopes,an FIB/SEM dual bea m system, a nd a correlative light-electron microscopy (CLEM) system, as well as a full set of cryo-sample preparation apparatuses including cryo-plungers, plasma clea ners a nd carbon evaporators.

X-ray Crystallography Facility

The X-ray Crystallography facility platform is one of the protein research platforms at the National Protein Research Facility (Tsinghua) Base. It is located in rooms B1019-1023, 1st Floor, Medical Science Building, Tsinghua University. The platform has been equipped the most comprehensive automated protein crystallography equipment in China that can provide powerful technical support for protein crystal screening, observation, optimization, data collection and structural solving solution for biology scientists. All platform equipment is available for internal and external researchers. We welcome all researchers from all the nationwide colleges and scientific research institutions to visit our university and take advantage of all the devices of the platform.

Neclear Magnetic Resonance Facility

The biomolecular Nuclear Magnetic Resonance (NMR) facility at Tsinghua University is a key component of Tsinghua University's Protein Technology Center. The facility consists of two state-of-the-art NMR spectrometers including a Bruker AVANCE III HD 800 MHz and a Bruker AVANCE III HD 600 MHz, both equipped with a TCI cryoprobe and an autosampler. These two spectrometers are open for academic users in and out of Tsinghua University, providing efficient and convenient service of NMR data acquisition and analysis.

Biocomputing Platform

The Biocomputing Platform of Protein Sciences Technology Center in Tsinghua University aims to support biological and medical computing researches. With growing capacity of big data processing and parallel computing, the computing facility is now able to provide service for large-scale data processing and analysis, especially, for high-resolution electron cryomicroscopy(Cryo-EM).

the Core Facility for Biomolecule Preparation and Characterization

The preparation, purification and identification of protein is the basis of all protein scientific research. the Core Facility for Biomolecule Preparation and Characterization at Technology Center for Protein Science, Tsinghua University have the scale effect since foundation, which can give full support to the research on protein structure and function. We provide four kinds of expression systems such as: E. Coli, Yeast, Insect cell and Mammalian cell suspended system to researchers from universities, research institutes, small biological companies and so on. We can also provide the protein related services, including molecular cloning, expression and purification, characterization，analysis of interaction，Screening of small molecule compounds and a series of related research.