余锦芳 博士

2021年 唐立新奖学金
2021年 清华大学结构生物学高精尖创新中心卓越博士生

主要科研领域与方向

猪严重腹泻综合征冠状病毒SADS-CoV和HKU2 spike蛋白的结构生物学研究；破伤风毒素及其中和抗体复合物的结构生物学研究；新型冠状病毒SARS-CoV-2 spike及其中和抗体复合物的结构生物学研究。

代表性论文

1. Jinfang Yu, Shuyuan Qiao, Runyu Guo, Xinquan Wang*. Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution. Nature Communications, 2020, 11:3070.

2. Jun Lan#, Jiwan Ge#, Jinfang Yu#, Sisi Shan#, Huan Zhou, Shilong Fan, Qi Zhang, Xuanling Shi, Qisheng Wang, Linqi Zhang*, Xinquan Wang*. Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature, 2020, 581:215-220.

3. Renhong Yan#, Ruoke Wang#, Bin Ju#, Jinfang Yu#, Yuanyuan Zhang#, Nan Liu#, Jia Wang, Qi Zhang, Peng Chen, Bing Zhou, Yaning Li, Yaping Shen, Shuyuan Zhang, Long Tian, Yingying Guo, Lu Xia,Xinyue Zhong, Lin Cheng, Xiangyang Ge, Juanjuan Zhao, Hong-Wei Wang, Xinquan Wang, Zheng Zhang*, Linqi Zhang*,Qiang Zhou*.Structural basis for bivalent binding and inhibition of SARSCoV-2 infection by human potent neutralizing antibodies.Cell Research, 2021 Mar 17:1–9.

4. Shuyuan Zhang#, Shuyuan Qiao#, Jinfang Yu#, Jianwei Zeng#, Sisi Shan, Long Tian, Jun Lan, Linqi Zhang, Xinquan Wang*. Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution. Nature Communications, 2021, 12:1607.

5. Manyu Xu#, Xiaopeng Zhu#, Jinfang Yu, Jinpeng Yu, Sulan Luo*, Xinquan Wang*. The crystal structure of Ac-AChBP in complex with alpha-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes. Protein Cell, 2017, 8:675-685.