邮箱：sai@tsinghua.edu.cn
副教授
2002-2006武汉大学应用物理系 学士
2006-2008德国斯图加特大学物理系 硕士
2009-2012德国哥廷根大学生物物理系 博士
2013-2017英国牛津大学粒子成像中心 博士后
2017-2018英国牛津大学粒子成像中心 副研究员
2018-至今清华大学生命科学学院 副教授
1. 冷冻电镜断层成像（cryo-ET）及原位结构生物学。高分辨cryo-ET是通过收集三维断层图像，再使用子断层图像平均法进行结构解析的前沿结构生物学方法。 Cryo-ET擅长对柔性巨型分子机器、细菌、细胞进行成像和蛋白结构解析，获得具生理意义的原位结构，是结构生物学的下一个突破。
2. 新发致病型囊膜病毒的组装及通过膜融合解胞的结构与功能。由于形态不均一，囊膜病毒的原位结构一直是结构生物学的挑战。我们使用cryo-ET解析全病毒结构，及在细胞中直接观测病毒生命活动的原位结构，希望回答：囊膜病毒如何组装，又如何通过膜融合解胞？目的找到病毒的弱点，并为抗体、疫苗设计提供新思路。
1. YeHong;BaoyingHuangJunxiaZhangChengPengWeizhengKongWenjieTan*SaiLi*;
Molecular Architecture of Monkeypox Mature Virus. bioRxiv 2024, DOI: 10.1101/2024.06.21.600031.
2. Dongyang Dong; Yutong Song; Shipo Wu; Busen Wang; Cheng Peng; Weizheng Kong; Zheyuan Zhang; Li-Hua Hou; Sai Li; Molecular basis of Ad5-nCoV Vaccine-Induced Immunogenicity. bioRxiv 2024, DOI: 10.1101/2024.06.21.600005
3. Maofei Chen#; Yutong Song#; Sensen Zhang#; Yitang Zhang#; Xudong Chen; Minghui Zhang; Meng Han; Xin Gao; Sai Li*; Maojun Yang*; Molecular architecture of mammalian pyruvate dehydrogenase complex, Protein & Cell, In press
4. Yutong Song#; Hangping Yao#; Nanping Wu#; Jialu Xu#; Zheyuan Zhang#; Cheng Peng; Shibo Li; Weizheng Kong; Yong Chen; Miaojin Zhu; Jiaqi Wang; Danrong Shi; Chongchong Zhao; Xiangyun Lu; Martín Echavarría Galindo; Sai Li; In situ architecture and membrane fusion of SARS-CoV-2 Delta variant, PNAS 2023; 120(18):e2213332120;
5. Dali Wang#; Jiaxuan Li#; Lei Wang; Yipeng Cao; Bo Kang; Xiangfei Meng; Sai Li*; Chen Song*; Toward Atomistic Models of Intact SARS-CoV-2 via Martini Coarse-Grained Molecular Dynamics Simulations, Quantitative Biology 2023; 11(4):421-433;
6. Ye Hong#; Yutong Song#; Zheyuan Zhang; Sai Li; Cryo-electron tomography: the resolution revolution and a surge of in situ virological discoveries, Annual Review of Biophysics 2023; 52(1):339-360;
7. Sai Li; Cryo-electron tomography of enveloped viruses, Trends in Biochemical Sciences, 2022; 47(2):173-186;
8. Hangping Yao#; Yutong Song#; Yong Chen#; Nanping Wu#; Jialu Xu#; Chujie Sun; Jiaxing Zhang; Tianhao Weng; Zheyuan Zhang; Zhigang Wu; Linfang Cheng; Danrong Shi; Xiangyun Lu; Jianlin Lei; Max Crispin; Yigong Shi; Lanjuan Li*; Sai Li*; Molecular architecture of the SARS-CoV-2 virus, Cell 2020; 183(3):730-738;
ESI hot paper
9. Xiaoling Wu#; Hua Yue#; Yuanyu Zhang#; Xiaoyong Gao; Xiaoyang Li; Licheng Wang; Yufei Cao; Miao Hou; Haixia An; Lin Zhang*; Sai Li*; Jingyuan Ma; He Lin; Yanan Fu; Hongkai Gu; Wenyong Lou; Wei Wei*; Richard N. Zare; Jun Ge*; Packaging and delivering enzymes by amorphous metal-organic frameworks, Nature Communications 2019; 10(1):5165;
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