李海涛 博士

教授
国家杰出青年基金获得者
谈家桢生命科学创新奖
中国肿瘤青年科学家奖
北京市自然科学二等奖（第一完成人）

主要科研领域与方向

表观遗传调控的分子结构基础。表观遗传调控关注染色质层面遗传信息组织与解读，具体机制涉及到组蛋白或DNA/RNA修饰、组蛋白变体、染色质重塑以及非编码RNA等。表观遗传机制在从基因表达调控到细胞命运决定等众多生命过程中发挥着重要作用。与此同时，越来越多证据揭示表观遗传调控异常会导致各种人类疾病的发生，尤其是癌症。我们主要采用结构生物学手段，并结合其它生物化学和细胞生物学技术，研究表观遗传调控和修饰生物学过程中的分子识别与催化事件。此外，我们也在积极开展基于微阵列芯片的生物分子互作工具开发和基于结构的药物发现研究。

代表性论文

1.     Haipeng Guan, Pei Wang, Pei Zhang, Chun Ruan, Yutian Ou, Bo Peng, Xiangdong Zheng, Jianlin Lei, Bing Li, Chuangye Yan^#, Haitao Li^# (2023) Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S. Nature 620:669-75.

2.     Wei Liu, Qiyan Yao, Xiaonan Su, Yafang Deng, Mo Yang, Bo Peng, Fan Zhao, Chao Du, Xiulan Zhang, Jinsong Zhu, Daliang Wang^#, Wenhui Li^#, Haitao Li^# (2023) Molecular insights into Spindlin1-HBx interplay and its impact on HBV transcription from cccDNA minichromosome. Nature Communication 14:4663.

3.     Lele Song, Xinyi Yao, Hangpeng Li, Bo Peng, Alan P Boka, Yiman Liu, Guochao Chen, Zhenyang Liu, Kaeli M Mathias, Lingbo Xia, Qinglan Li, Mustafa Mir, Yuanyuan Li^#, Haitao Li^#, Liling Wan^# (2022) Hotspot mutations in the structured ENL YEATS domain link aberrant transcriptional condensates and cancer. Mol Cell 82: 4080-4098

4.     Shuangping Zheng, Yucong Bi, Haining Chen, Bo Gong, Shunji Jia, Haitao Li^# (2021) Molecular basis for bipartite recognition of histone H3 by the PZP domain of PHF14. Nucleic Acids Res 49:8961-8973

5.       Xiangle Ren, Yang Zhou, Zhaoyu Xue, Ning Hao, Yuanyuan Li, Xiaohuan Guo, Daliang Wang, Xiaobing Shi, Haitao Li^# (2021) Histone benzoylation serves as an epigenetic mark for DPF and YEATS family proteins. Nucleic Acids Res 49: 114-126

6.       Anja Armache, Shuang Yang, Alexia Martinez de Paz, Lexi E Robbins, Ceyda Durmaz, Jin Q Cheong, Arjun Ravishankar, Andrew W Daman, Dughan J Ahimovic, Thaís Klevorn, Yuan Yue, Tanja Arslan, Shu Lin, Tanya Panchenko, Joel Hrit, Miao Wang, Samuel Thudium, Benjamin A Garcia, Erica Korb, Karim-Jean Armache, Scott B Rothbart, Sandra B Hake, C David Allis, Haitao Li^#, Steven Z Josefowicz^#  (2020) Histone H3.3 phosphorylation amplifies stimulation-induced transcription. Nature 583: 852–857

7.       Zheng Li, Shuai Zhao, Raman V Nelakanti, Kaixuan Lin, Tao P Wu, Myles H Alderman III, Cheng Guo, Pengcheng Wang, Min Zhang, Wang Min, Zongliang Jiang, Yinsheng Wang, Haitao Li^#, Andrew Z Xiao^# (2020) N6-methyladenine in DNA antagonizes chromatin organizer SATB1 in early development. Nature 583: 625–630

8.       Min Zhang, Shumin Yang, Raman Nelakanti, Wentao Zhao, Gaochao Liu, Zheng Li, Xiaohui Liu, Tao Wu, Andrew Xiao^#, Haitao Li^# (2020) Mammalian ALKBH1 serves as an N6-mA demethylase of unpairing DNA. Cell Res 30: 197-210

9.       Shuai Zhao, Lingling Cheng, Yifei Gao, Baichao Zhang, Xiangdong Zheng, Liang Wang, Pilong Li^#, Qianwen Sun^#, Haitao Li^# (2019) Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation. Cell Res 29, 54-66

10.   Yuanyuan Li, Benjamin R Sabari, Tatyana Panchenko, Hong Wen, Dan Zhao, Haipeng Guan, Liling Wan, He Huang, Zhanyun Tang, Yingming Zhao, Robert G Roeder, Xiaobing Shi, C David Allis^#, Haitao Li^# (2016) Molecular coupling of histone crotonylation and active transcription by AF9 YEATS domain. Mol Cell 62:181-193