联系方式

电话:+86-10-62789401

邮箱:xinquanwang@mail.tsinghua.edu.cn

王新泉 博士

教授
北京生物结构前沿研究中心常务副主任
2014无锡应用科技生命科学与化学奖
2010中国教育部新世纪人才计划
2010霍英东中国青年教师教育基金会

个人履历

1990-1995复旦大学 学士

1995-2000中国科学院生物物理研究所 博士

2000-2003中国科学院生物物理研究所 助理研究员

2003-2008斯坦福大学 博士后

2008-2013清华大学生命科学学院 Tenure系列副教授

2013-至今 清华大学生命科学学院 教授

主要科研领域与方向

主要研究方向为结构生物学。利用生物大分子及复合物结构测定为主要手段,结合其他生物化学及生物物理技术,研究细胞因子介导的宿主免疫反应和病毒侵染及免疫逃逸的结构机理。

代表性论文

1.Huiqing Chen, Xiaofei Ge, Chun Li, Jianwei Zeng#Xinquan Wang # (2024). Structure and assembly of the human IL-12 signaling complex. Structure, Jul 25:S0969-2126(24)00273-9.

2.Shuyuan Qiao, Xinquan Wang # (2024). Structural determinants of spike infectivity in bat SARS-like coronaviruses RsSHC014 and WIV1. J Virol., Jul 19:e0034224. doi: 10.1128/jvi.00342-24.

3. Shuyuan Zhang, Qingtai Liang , Xinheng He, Chongchong Zhao,  Wenlin Ren Ziqing Yang Ziyi Wang Qiang Ding Haiteng Deng Tong Wang#Linqi Zhang#, Xinquan Wang# (2022). Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2. Cell Res., 32(3):315-318.

4. Shuyuan Zhang, Shuyuan Qiao, Jinfang YuJianwei ZengSisi ShanLong TianJun LanLinqi Zhang, Xinquan Wang# (2021). Bat and pangolin coronavirus spike glycoprotein structures provide insights into SARS-CoV-2 evolution. Nature Commun., 12(1), 1607.

5. Jinfang YuShuyuan QiaoRunyu Guo, Xinquan Wang# (2020).  Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution. Nature Commun., 11, 3070.

6. Bin JuQi ZhangJiwan GeRuoke WangJing SunXiangyang GeJiazhen YuSisi ShanBing ZhouShuo SongXian TangJinfang YuJun LanJing YuanHaiyan WangJuanjuan ZhaoShuye ZhangYouchun WangXuanling ShiLei LiuJincun ZhaoXinquan Wang#, Zheng Zhang#Linqi Zhang# (2020). Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature, doi: 10.1038/s41586-020-2380-z.

7. Jun LanJiwan GeJinfang YuSisi ShanHuan ZhouShilong FanQi ZhangXuanling ShiQisheng WangLinqi Zhang#, Xinquan Wang# (2020). Structure of the SARS- CoV-2 spike receptor-binding domain bound to the ACE2 receptor. Nature, doi: 10.1038/s41586-020-2180-5.

8. Haixia ZhouYingzhu ChenShuyuan ZhangPeihua NiuKun QinWenxu JiaBaoying HuangSenyan ZhangJun LanLinqi ZhangWenjie Tan#, Xinquan Wang# (2019). Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spikeglycoprotein. Nat Commun., 10(1):3068.

9. Wenfei Song Miao Gui, Xinquan Wang#, Ye Xiang# (2018). Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cellreceptor ACE2. PLoS Pathog.,14(8):e1007236.

10. Miao Gui Wenfei Song Haixia Zhou Jingwei Xu Silian Chen Ye Xiang#, Xinquan Wang# (2017). Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell Res., 27(1):119-129.