赵帅 博士

2024 国家优秀青年科学基金（海外）

主要科研领域与方向

实验室的研究方向为内源性逆转录病毒（ERV）元件的空间生物学与肿瘤生物学，主要研究方向包括：

1. 新型ERV调控元件的发现与靶向。

2. 肿瘤发生发展中ERV元件的空间生物学解析。

3. ERV元件调控蛋白在肿瘤表观遗传及肿瘤免疫中的功能。

代表性论文

1. Zhao S*, Lu J*, Pan B, Fan H, Byrum S, Xu C, Kim A, Guo Y, Kanchi K, Gong W, Sun T, Storey A, Burkholder N, Mackintosh S, Kuhlers P, Edmondson R, Strahl B, Diao Y, Tackett A, Raab J, Cai L, Song J^#, Wang G^# (2023) TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons. Nature 623: 633–642

2. Li Z*, Zhao S*, Nelakanti R*, Lin K*, Wu T*, Alderman III M, Guo C, Wang P, Zhang M, Min W, Jiang Z, Wang Y, Li H^#, Xiao A^# (2020) N6-methyladenine in DNA antagonizes SATB1 in early development. Nature 583: 625-630

3. Zheng Q*, Weekley B*, Vinson D*, Zhao S*, Bastle R*, Thompson R, Stransky S, Ramakrishnan A, Cunningham A, Dutta S, Chan J, Salvo GD, Chen M, Zhang N, Wu J, Fulton S, Kong L, Wang H, Zhang B, Vostal L, Upad A, Dierdorff L, Shen L, Molina H, Sidoli S, Muir T, Li H^#, David Y^#, Maze I^# (2025) Histone monoaminylation dynamics are regulated by a single enzyme and promote neural rhythmicity. Nature 637: 974-982

4. Zhao S, Allis CD, Wang G (2021) The language of chromatin modification in human cancers. Nat. Rev. Cancer 21: 413-430 (Cover Story)

5. Zhao S*, Chuh K*, Zhang B*, Xu N, Xue Y, Liu X, Farrelly F, Thompson R, Roeder R, Maze I^#, Muir T^#, Li H^# (2021) Histone H3Q5 serotonylation stabilizes H3K4me3 and potentiates its readout by TAF3. PNAS 118 (6) e2016742118

6. Zhao S*, Cheng L*, Gao Y*, Zhang B*, Zheng X, Wang L, Li P^#, Sun Q^#, and Li H^# (2019) Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation. Cell Research 29 (1): 54-66

7. Zhao S*, Zhang B*, Yang M, Zhu J, and Li H (2018) Systematic profiling of histone readers in Arabidopsis thaliana. Cell Reports 22: 1090-1102

8. Zhao S*, Yang M*, Zhou W, Zhang B, Cheng Z, Huang J. Zhang M, Wang Z, Wang R, Chen Z, Zhu J^#, and Li H^# (2017) Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology. PNAS 114: E7245-E7254

9. Zhao S, Yue Y, Li Y, Li H (2019) Identification and characterization of “readers” for novel histone modifications. Curr Opin Chem Biol 51: 57-65

10. Zhao S*, Zhang X*, and Li H (2018) Beyond histone acetylation – writing and erasing histone acylations. Curr Opin Struc Biol 53:169–177