邮箱：jinxq@mail.tsinghua.edu.cn
2019 北京市优秀毕业生
2019 北京大学优秀毕业生
2010.9-2014.7 吉林大学药学院，本科
2014.9-2019.7 北京大学药学院，博士
2019.7-2023.7 清华大学生命学院，博士后
2023.8-至今 清华大学生命学院，助理研究员
利用结构生物学、电生理学等研究离子通道工作机制；靶向离子通道药物的研发，生理及病理过程中离子通道的功能及机制等。
1.
Wu Q #, Huang J #, Fan X #, Wang K #, Jin X #, Huang G,
Li J, Pan X, Yan N. Structural
mapping of Nav1.7 antagonists. Nat Commun. 2023 Jun
3;14(1):3224. doi:
10.1038/s41467-023-38942-3. PMID: 37270609; PMCID: PMC10239435.
（IF=17.694）
2. Huang J #, Fan X #, Jin X, Jo S,
Zhang HB, Fujita A, Bean BP, Yan N. Cannabidiol
inhibits Nav channels through two distinct binding sites. Nat Commun. 2023 Jun
17;14(1):3613. doi: 10.1038/s41467-023-39307-6. PMID: 37330538; PMCID:
PMC10276812. （IF=17.694）
3. Huang, X. #, Jin, X. #, Huang, G.
#, Huang, J., Wu, T., Li, Z., Chen, J., Kong, F., Pan, X.,
and Yan, N. (2022). Structural basis for high-voltage activation and subtype-specific
inhibition of human Na(v)1.8. Proc Natl Acad Sci U S A. 119, e2208211119. (# 共同作者)
（IF=12.779）
4. Huang, G. #, Wu, Q. #, Li, Z. #, Jin, X. #, Huang,
X., Wu, T., Pan, X., and Yan, N. (2022).
Unwinding and spiral sliding of S4 and domain rotation of VSD during the
electromechanical coupling in Na(v)1.7. Proc Natl Acad Sci U S A. 119, e2209164119. (#
共同作者) （IF=12.779）
5. Yao, X. #, Gao, S. #, Wang, J., Li,
Z., Huang, J., Wang, Y., Wang, Z., Chen, J., Fan, X.,
Wang, W., Jin, X., et al. (2022). Structural basis for the severe adverse
interaction of
sofosbuvir and amiodarone on L-type Ca(v) channels. Cell 185,
4801-4810.e4813. (# 共同
作者) （IF=66.85）
6. Pan X#, Li Z#, Jin X#, Zhao Y#,
Huang G#, Huang X, Shen Z, Cao Y, Dong M, Lei J,
Yan N. Comparative structural analysis of human Nav1.1 and Nav1.5 reveals
mutational
hotspots for sodium channelopathies. Proc Natl Acad Sci U S A. 2021 Mar 16;118(11):
e2100066118. (# 共同作者)（IF=12.779）
7. Li Z#, Jin X#, Wu T#,
Huang G#, Wu K, Lei J, Pan X, Yan N. Structural Basis for Pore
Blockade of the Human Cardiac Sodium Channel Nav1.5 by the Antiarrhythmic Drug
Quinidine. Angew Chem
Int Ed Engl. 2021 Mar 8. doi:
10.1002/anie.202102196. Epub
ahead of print. PMID: 33684260. (# 共同作者) （IF=16.823）
8. Ma Y#, Xie H#, Du X#, Wang L#, Jin X#, Zhang
Q#, Han Y, Sun S, Wang L, Li X, Zhang
C, Wang M, Li C, Xu J, Huang Z, Wang X, Chai Z, Deng H. In vivo chemical
reprogramming of astrocytes into neurons. Cell Discov. 2021 Mar
2;7(1):12. doi:
10.1038/s41421-021-00243-8. PMID: 33649311; PMCID: PMC7921425. (# 共同作者)
（IF=38.09）
9. Chi X#, Jin X#, Chen Y#,
Lu X#, Tu X, Li X, Zhang Y, Lei J, Huang J, Huang Z, Zhou Q,
Pan X. Structural insights into the gating mechanism of human SLC26A9 mediated
by its
C-terminal sequence. Cell
Discov. 2020 Aug 10;6:55. doi:
10.1038/s41421-020-00193-7.
PMID: 32818062; PMCID: PMC7417587. (# 共同作者) （IF=38.09）
10. Jin X, Chen Q,
Song Y, Zheng J, Xiao K, Shao S, Fu Z, Yi M, Yang Y, Huang Z.
Dopamine D2 receptors regulate the action potential threshold by modulating
T-type
calcium channels in stellate cells of the medial entorhinal cortex. J Physiol. 2019
Jul;597(13):3363-3387. doi: 10.1113/JP277976. Epub 2019 May 28. PMID: 31049961.
（IF=6.228）
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