Jianlin Lei Ph.D.

ICSB Executive Committee Member｜Director of cryo-EM facility

Main Research Fields

The focus of my research is the development and application of new technology and methods in cryo-electron microscopy (cryo-EM). More specifically, I am interested in the development of techniques involved in high-throughput automated cryo-EM imaging as well as approaches to improve the performance of electron microscopes.

Selected Publications

1. Agirrezabala, X., Lei, J., Brunelle, J., Ortiz-Meoz, R., Green, R., and Frank, J. (2008). Visualization of the Hybrid State of tRNA Binding Promoted by Spontaneous Ratcheting of the Ribosome. Molecular Cell 32, 190–197.

2. Li, W., Agirrezabala, X., Lei, J., Bouakaz, L., Brunelle, L., Ortiz-Meoz, R., Green, R., Sanyal, S., Ehrenberg, M. and Frank, J. (2008). Recognition of aminoacyl-tRNA: a common molecular mechanism revealed by cryo-EM. The EMBO Journal 27, 3322-3331.

3. Lei, J., and Frank, J. (2005). Automated acquisition of cryo-electron micrographs for Single particle reconstruction on an FEI Tecnai electron microscope. Journal of Structural Biology 150, 69–80.

4. Weidner, E., Frey, F., Lei, J., Pedersen, B., Paulmann, C., and Morgenroth, W. (2004). Disordered quasicrystals: diffuse scattering in decagonal Al-Ni-Fe. J. Appl. Cryst. 37, 802-807

5. Weidner, E., Lei, J., Frey, F., Wang, R., and Grushko, B. (2002). Diffuse scattering in decagonal Al–Ni–Fe. Journal of Alloys and Compounds 342, 156-158.

6. Lei, J., Wang, R., Yin, J., and Duan, X. (2002). Diffuse electron scattering determination of elastic constants of Al–Pd–Mn icosahedral quasicrystal. Journal of Alloys and Compounds 342, 326-329.

7. Wang, R., Hu, C., Lei, J. (2001). Theory of diffuse scattering of quasicrystals due to fluctuations of thermalised phonons and phasons. Phys. Stat. Sol. (b) 225, 21-34.

8. Lei, J., Wang, R., Hu, C., and Ding, D. (2000). Diffuse scattering from dodecagonal quasicrystals. Eur. Phys. J. B 13, 21-30.

9. Wang, R., Hu, C., Lei, J., and Ding, D. (2000). Theoretical aspects of thermal diffuse scattering from quasicrystals. Phys. Rev. B 61, 5843-5845.

10. Lei, J., Wang, R., Hu, C., and Ding, D., (1999). Diffuse scattering from decagonal quasicrystals. Phys. Rev. B 59, 822-828.

11. Lei, J., Hu, C., Wang, R., and Ding, D., (1999). Diffuse scattering from octagonal quasicrystals. J. Phys.: Condens. Matter 11, 1211-1223.

12. Lei, J., Wang, R., Hu, C., and Ding, D. (1998). Diffuse scattering from pentagonal quasicrystals. Phys. Lett. A 247, 343-352.

13. Wang, J., Lei, J., and Wang, R. (1998). Diffraction pattern calculation and phase identification of hypothetical crystalline C3N4. Phys. Rev. B 58, 11890-11895.