Xinquan Wang_Beijing Frontier Research Center for Biological Structure

Contact information

Email：xinquanwang@mail.tsinghua.edu.cn

Xinquan Wang Ph.D.

Professor | FRCBS Executive Committee Member | 2014 WuXi AppTech Life Science and Chemistry Awards | 2010 Program for New Century Talents, The Ministry of Education of China | 2010 Fok Ying-Tong Education Foundation for Young Teachers in China

Resume

1990-1995Fudan University B.S.

1995-2000Institute of Biophysics, Chinese Academy of Sciences Ph.D.

2000-2003Institute of Biophysics, Chinese Academy of Sciences Research Associate

2003-2008Stanford University Postdoc.

2008-2013School of Life Sciences, Tsinghua University Tenure Track Associate Professor

2013-PresentSchool of Life Sciences, Tsinghua University Tenured professor

Main Research Fields

We investigate cell surface receptor recognition and activation using structural biology approaches. One major research interest in our laboratory is to elucidate the receptor-ligand interactions and activation in the interleukin 1 (IL-1) and other cytokine families that play important roles in host inflammatory response and regulation. We also study macromolecular interactions that mediate the cell entry of highly pathogenic coronaviruses and influenza viruses and host neutralization by potent antibodies.

Selected Publications

Zhang S, Liang Q, He X, Zhao C, Ren W, Yang Z, Wang Z, Ding Q, Deng H, Wang T*, Zhang L*, Wang X*. Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2. Cell Res. (2022) 32(3):315-318.
2. Ge J, Wang R, Ju B, Zhang Q, Sun J, Chen P, Zhang S, Tian Y, Shan S, Cheng L, Zhou B, Song S, Zhao J, Wang H, Shi X, Ding Q, Liu L, Zhao J, Zhang Z*, Wang X*, Zhang L*. (2021) Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nature Communications, 12(1):250.
3.Zhang, S., Qiao, S., Yu, J., Zeng, J. & Wang X*.(2021). Bat and pangolin coronavirus spike glycoprotein structures provide insights into sars-cov-2 evolution. Nature Communications, 12(1), 1607.
4.Yu J, Qiao S, Guo R & Wang X*. Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution. Nat Commun 11, 3070, doi: 10.1038/s41467-020-16876-4 (2020)
5.Ju B, Zhang Q, Ge J, Wang R, Sun J, Ge X, Yu J, Shan S, Zhou B, Song S, Tang X, Yu J, Lan J, Yuan J, Wang H, Zhao J, Zhang S, Wang Y, Shi X, Liu L, Zhao J, Wang X*, Zhang Z & Zhang L. Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature. 2020 May 26. doi: 10.1038/s41586-020-2380-z (2020).
6.Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L*, Wang X*.(2020)Structure of the SARS- CoV- 2spikereceptor-bindingdomainbound to the ACE2receptor.Nature, doi: 10.1038/s41586-020-2180-5.
7. Zhou H, Chen Y, Zhang S, Niu P, Qin K, Jia W, Huang B, Zhang S, Lan J, Zhang L, Tan W, Wang X*. (2019) Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spikeglycoprotein. Nat Commun., 10(1):3068.
8. Song W, Gui M, Wang X, Xiang Y.Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cellreceptor ACE2. PLoS Pathog.,14(8):e1007236.
9.Gui M, Song W, Zhou H, Xu J, Chen S, Xiang Y*, Wang X*.(2017) Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell Res., 27(1):119-129.
10.Zuo T, Sun J, Wang G, Jiang L, Zuo Y, Li D, Shi X, Liu X, Fan S, Ren H, Hu H, Sun L, Zhou B, Liang M, Zhou, Paul*, Wang X*, Zhang L*. (2015)Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection. Nature Communications , 6: 8855.
11.Yu X, Zhang S, Jiang L, Cui Y, Li D, Wang D, Wang, N, Fu L, Shi X, Li Z, Zhang L*, Wang X*. (2015)Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27. Scientific Reports, 5:13133.
12.Jiang L, Wang N, Zuo T, Shi X, Poon K, Wu Y, Gao F, Li D, Wang R, Guo J, Fu L, Yuen KY, Zheng B*, Wang X*, Zhang Linqi*.(2014) Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein. Science Translational Medicine , 6 (234):234ra59.
13.Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S*, Wang X*. (2013)Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci USA., 110:14918-23.
14.Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen YH, Zhang L*, Wang X*.(2013) Structure of MERS-CoV spike receptor binding domain complexed with human receptor DPP4. Cell Res., 23: 986-93.
15.Wang D, Huang B, Zhang S, Yu X, Wu W, Wang X*. (2013)Structural basis for R-Spondin recognition by LGR4/5/6 receptors. Genes Dev., 27:1339-44.

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