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Ye Xiang    Ph.D.

Principal Investigator

Young 1000-Talent Plan


1994-1998    Peking University    B.S

1998-2003    Institute of Biophysics, Chinese Academy of Sciences    Ph.D candidate

2005-2010    Department of Biological Sciences, Purdue University    Postdoc

2010-2012    Department of Biological Sciences, Purdue University    Assistant research scientist

2013-Present  School of Medicine, Tsinghua University    Assistant professor

Main Research Fields

Our research group is interested in the molecular mechanisms of the assembly and function of complex molecular machineries. We use cryo-electron microscopy and x-ray crystallography for our studies.

Selected Publications

1. Misasi J*, Gilman MS*, Kanekiyo M*, Gui M*, Cagigi A, Mulangu S, Corti D, Ledgerwood JE, Lanzavecchia A, Cunningham J, Muyembe-Tamfun JJ, Baxa U, Graham BS, Xiang Y#, Sullivan NJ#, McLellan JS. Science. 2016 Feb 25. In press. #Corresponding author.

2. Zhu DY, Wang L, Shang G, Liu X, Zhu J, Wang L, Lu DF, Kan B, Zhang JR, Xiang Y# (2014) Structural biochemistry of a Vibrio cholerae dinucleotide cyclase reveals cyclase activity regulation by folates. Mol Cell, 55:931-7. #Correspongding author.

3. Sun S*, Xiang Y*, Zhang XZ, Wataru A, Holdaway H, Pal P, Dimond M, Nabel G, Rossmann MG (2013) Structural analyses at pseudo atomic resolution of Chikungunya virus and antibodies show mechanisms of neutralization. elife ,DOI: http://dx.doi.org/10.7554/eLife.00435. *Co-first author.

Zhang X, Sun S, Xiang Y, Wong J, Klose T, Raoult D, Rossmann MG. (2012) Structure of Sputnik, a virophage, at 3.5-Å resolution. PNAS, 6:18431-6.

4. Sun S, Gao S, Kondabagil K, Xiang Y, Rossmann MG, Rao VB (2012) Structure and function of the small te rminase component of the DNA packaging machine in T4-like bacteriophages. PNAS, 109:817-822.

5. Zhang X, Xiang Y, Dunigan DD, Klose T, Chipman PR, Van Etten JL, Rossmann MG. (2011) Three-dimensional structure and function of the Paramecium bursaria chlorella virus capsid. PNAS, 108:14837-14842.

6. Xiang Y, Rossmann MG. (2011) Structure of bacteriophage Φ29 head fibers has a supercoiled triple repeating helix-turn-helix motif. PNAS, 108:4806-4810.

7. Xiang Y, Baxa U, Zhang Y, Steven AC, Lewis GL, Van Etten JL, Rossmann MG. (2010) Crystal structure of a virus encoded putative glycosyltransferase. J Virol. 84:12265-12273.


Tel: +86-10-62772587 (Lab)

Email: yxiang@mail.tsinghua.edu.cn