施一公 博士
教授
中国科学院院士
美国科学院外籍院士
美国人文与科学院外籍院士
中心学术指导委员会主席
个人履历
1985-1989清华大学生物科学与技术系 学士
1990-1995美国约翰霍普金斯大学医学院 博士
1995美国约翰霍普金斯大学医学院 博士后
1996-1997纪念斯隆-凯特琳癌症中心 博士后
1998-2001普林斯顿大学分子生物学系 助理教授
2001-2003美国普林斯顿大学分子生物学系 副教授
2003-2008美国普林斯顿大学分子生物学系 教授
2007-2008美国普林斯顿大学分子生物学系 Warner-Lambert/Parke-Davis教授
2008-至今清华大学生命科学学院 教授
主要科研领域与方向
主要运用结构生物学、生物化学和生物物理的手段研究RNA剪接、细胞凋亡等细胞内生物大分子机器的结构与功能，以及γ-分泌酶介导的阿尔茨海默症的分子机制。
代表性论文
1. Guanghui Yang, Rui Zhou, Xuefei Guo, Chuangye Yan, Jianlin Lei, Yigong Shi# (2021). Structural basis of γ-secretase inhibition and modulation by small molecule drugs. Cell, 184(2):521-533.
2. Gaoxingyu Huang, Yanqing Zhang, Xuechen Zhu, Chao Zeng, Qifan Wang, Qiang Zhou, Qinghua Tao, Minhao Liu, Jianlin Lei, Chuangye Yan and Yigong Shi# (2020). Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex by cryo-electron microscopy single particle analysis. Cell Research, 30(6):520–531.
3. Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei, Yigong Shi# (2019). Recognition of the amyloid precursor protein by human γ-secretase. Science, 363(6428):eaaw0930.
4. Guanghui Yang, Rui Zhou, Qiang Zhou, Xuefei Guo, Chuangye Yan, Meng Ke, Jianlin Lei & Yigong Shi# (2019). Structural basis of Notch recognition by human γ-secretase. Nature, 565(7738):192-197.
5. Rui Bai, Ruixue Wan, Chuangye Yan, Jianlin Lei, Yigong Shi# (2018). Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation. Science, 360(6396):1423-1429.
6. Xiechao Zhan, Chuangye Yan#, Xiaofeng Zhang, Jianlin Lei, Yigong Shi# (2018). Structure of a human catalytic step I spliceosome. Science, 359(6375): 537-545.
7. Xiaofeng Zhang, Chuangye Yan#, Jing Hang, Lorenzo I. Finci, Jianlin Lei, and Yigong Shi# (2017). An atomic structure of the human spliceosome. Cell, 169(5):918-929.
8. Rui Bai, Chuangye Yan, Ruixue Wan, Jianlin Lei, and Yigong Shi# (2017). Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae. Cell, 171(7):1589-1598.
9. Chuangye Yan, Ruixue Wan, Rui Bai, Gaoxingyu Huang, Yigong Shi# (2016). Structure of a yeast catalytically activated spliceosome at 3.5 Å resolution. Science, 353(6302):904-911.
10. Ruixue Wan, Chuangye Yan, Rui Bai, Gaoxingyu Huang, Yigong Shi# (2016). Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution. Science, 353(6302):895-904.
11. Chuangye Yan, Jing Hang, Ruixue Wan, Min Huang, Catherine C. L. Wong, Yigong Shi# (2015). Structure of a yeast spliceosome at 3.6-angstrom resolution. Science, 349(6253):1182-1191.
12. Jing Hang, Ruixue Wan, Chuangye Yan, and Yigong Shi# (2015). Structural basis of pre-mRNA splicing. Science, 349(6253):1191-1198.
13. Mengying Zhou, Yini Li, Qi Hu, Xiaochen Bai, Weijiao Huang, Chuangye Yan, Sjors H. W. Scheres#, and Yigong Shi# (2015). Atomic structure of the apoptosome: mechanism of cytochrome c- and dATP-mediated activation of Apaf-1. Genes & Development, 29(22):2349-2361.
14. Peilong Lu, Xiao-chen Bai, Dan Ma, Tian Xie, Chuangye Yan, Linfeng Sun, Guanghui Yang, Yanyu Zhao, Rui Zhou, Sjors H. W. Scheres# & Yigong Shi# (2014). Three-dimensional structure of human γ-secretase. Nature, 512(7513): 166-170.
15. Shiqian Qi, Yuxuan Pang, Qi Hu, Qun Liu, Hua Li, Yulian Zhou, Tianxi He, Qionglin Liang, Yexing Liu, Xiaoqiu Yuan, Guoan Luo, Huilin Li, Jiawei Wang, Nieng Yan#, and Yigong Shi# (2010). Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4. Cell, 141(3):446-457.
