联系方式

董晨 博士

国际细胞因子学会青年研究者奖
国际干扰素与细胞因子研究协会Milstein青年研究者奖
美国免疫学家协会BD Biosciences 研究者奖
美国科学促进会会士
汤森路透 “高被引科学家”
科睿唯安(原汤森路透)“高被引科学家”
国际细胞因子与干扰素协会BioLegend-William.E.Paul细胞因子杰出研究奖
Dr.Tsai-Fan Yu Foundation Legacy Award

个人履历

1985-1989 中国武汉大学 学士

1990-1996 美国阿拉巴马大学伯明翰分校 博士

1997-2000 美国耶鲁大学 博士后

2000-2004 美国华盛顿大学(西雅图)免疫学系 助理教授

2004-2008 美国德克萨斯大学安德森肿瘤中心免疫学系 终身副教授

2008-2014 美国德克萨斯大学安德森肿瘤中心免疫学系 终身教授

2008 -2013 美国德克萨斯大学安德森肿瘤中心炎症与肿瘤中心 主任

2013-至今清华大学医学院 教授

2013-2016清华大学医学院 副院长

2014-至今 清华大学免疫学研究所 所长

2015-至今北大-清华大学生命联合中心,清华大学 副主任(清华)

2016-至今 清华大学医学院 院长

2017-至今 清华大学慢性疾病的免疫学研究北京市重点实验室 主任

主要科研领域与方向

T淋巴细胞分化与功能;细胞因子在炎症中的功能与信号传导;免疫耐受和肿瘤免疫。

代表性论文

1. Liu, X., Chen, X., Zhong, B., Wang, A., Wang, X., Chu, F., Nurieva, R. I., Yan, X., Chen, P., van der Flier, L. G., Nakatsukasa, H., Neelapu, S. S., Chen, W., Clevers, H., Tian, Q., Qi, H., Wei, L. and Dong, C. Transcription factor Achaete-Scute homologue 2 initiates T follicular helper cell development. (2014) Nature. 507: 513–518.

2. Reynolds, J. M., Lee, Y.-H., Shi, Y., Angkasekwinai, P., Nallaparaju, K. C., Flaherty, S., Chang, S. H., Watarai, H. and Dong, C. Interleukin-17B antagonizes interleukin-25-mediated mucosal inflammation. (2015). Immunity. 42:692-703.

3. Ichiyama, K., Chen, T., Wang, X., Yan, X., Kim, B. S., Tanaka, S., Ndiaye-Lobry, D., Deng, Y., Zou, Y., Zheng, P., Tian, Q., Aifantis, I., Wei, L. and Dong, C. The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells. (2015) Immunity. 42:613-626.

4. Liu, X., Lu, H., Chen, T., Nallaparaju, K. C., Yan, X., Tanaka, S., Ichiyama, K., Zhang, X., Zhang, L., Wen, X., Tian, Q., Bian, X., Jin, W., Lai, W. and Dong, C. Genome-wide analysis identifies Bcl6-controlled regulatory networks during T follicular helper (Tfh) cell differentiation. (2016) Cell Reports. 14:1735-1747.

5. Ichiyama, K., Gonzalez-Martin, A., Kim, B.-S., Jin, H. Y., Jin, W., Xu, W., Sabouri-Ghomi, M., Xu, S., Zheng, P., Xiao, C. and Dong, C. The microRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo1 expression. (2016) Immunity. 44: 1284–1298.

6. Ding, X., Wang, A., Ma, X., Demarque, M., Jin, W., Xin, H., Dejean, A. and Dong, C. Protein SUMOylation is required for regulatory T cell expansion and function. (2016) Cell Reports. 16:1055-1066.

7. Xu, T, Stewart, K. M., Wang, X., Liu, K., Xie, M., Kyu Ryu, J., Li, K., Ma, T., Wang, H., Ni, L., Zhu, S., Cao, N., Zhu, D., Zhang, Y., Akassoglou, K., Dong, C.*, Driggers, E. M.*, Ding, S.* Metabolic control of TH17 and induced Treg cell balance by an epigenetic mechanism. (2017) Nature. 548:228-233. (* co-correspondent authors)

8. Li, J., Lee, Y., Li, Y., Jiang, Y., Lu, H., Zang, W., Zhao, X., Liu, L., Chen, Y., Tan, H., Yang, Z., Zhang, M. Q., Mak, T. W., Ni, L. and Dong, C. Co-inhibitory molecule B7 superfamily member 1 expressed by tumor-infiltrating myeloid cells induces dysfunction of anti-tumor CD8+ T cells. (2018) Immunity. 48:773-786

9. Xu, M., Lu, H., Wu, Y., Liu, K., Shi, Y., An, H., Zhang, J., Wang, X., Lai, Y. and Dong, C. An IL-25-mediated autoregulatory circuit in keratinocytes plays a pivotal role in psoriatic skin inflammation. (2018) Immunity. 48:787-798

10. Tanaka K, Martinez GJ, Yan X, Long W, Ichiyama K, Chi X, Kim BS, Reynolds JM, Chung Y, Tanaka S, Liao L, Nakanishi Y, Yoshimura A, Zheng P, Wang X, Tian Q, Xu J, O'Malley BW, Dong C. Regulation of Pathogenic T Helper 17 Cell Differentiation by Steroid Receptor Coactivator-3. (2018) Cell Reports. 23(8):2318-2329.