联系方式

电话:+86-10-62782664

邮箱:lixueming@mail.tsinghua.edu.cn

个人主页

李雪明 博士

研究员 中心学术指导委员会成员

个人履历

1998-2002北京科技大学材料物理系 学士

2002-2005北京科技大学材料物理与化学系 硕士

2005-2009中国科学院物理研究所 博士

2009-2013加州大学旧金山分校 博士后

2014- 至今清华大学生命科学学院 研究员

主要科研领域与方向

主要从事冷冻电子显微学理论和方法研究,着重于开发和利用最新的电子显微学技术,以提高冷冻电子显微学三维重构的分辨率到原子水平;同时致力于将电子显微学应用到结构生物学研究中去,以解决与结构相关的重要生物学问题。

代表性论文

1. Zhao Q, Zhou H, Chi S, Wang Y, Wang J, Geng J, Wu K, Liu W, Zhang T, Dong MQ, Wang J, Li X*, Xiao B*. (2018) Structure and mechanogating mechanism of the Piezo1 channel. Nature, 554(7693):487-492.

2. Zhou X, Li M, Su D, Jia Q, Li H, Li X*, Yang J*. (2017) Cryo-EM structures of the human endolysosomal TRPML3 channel in three distinct states. Nat Struct Mol Biol., 24(12):1146-1154.

3. Liu X, Li M, Xia X, Li X*, Chen Z *. (2017) Mechanism of chromatin remodeling from the Snf2-nucleosome structure. Nature, 544(7651):440-445.

4. Li M, Zhou X, Wang S, Michailidis I, Gong Y, Su D, Li H, Li X*, Yang J*. (2017) Cryo-EM structure of a eukaryotic cyclic nucleotide-gated channel. Nature, 542, 60-65.

5. Yan Z, Yin M, Xu D, Zhu Y, Li X*. (2017) Structural Insights into Secretin Translocation Channel in Type II Secretion System. Nat Struct Mol Biol, 24, 177-183.

6. Zhang L, Wang X, Fan F, Wang HW, Wang J*, Li X*, Sui SF*. (2017) Cryo-EM structure of Nma111p, a unique HtrA protease composed of two protease domains and our PDZ domains. Cell Res., 27(4):582-585.

7. Wang F, Gong H, Liu G, Li M, Yan C, Xia T*, Li X*, Zeng J*. (2016) DeepPicker: a Deep Learning Approach for Fully Automated Particle Picking in Cryo-EM. J Struct Biol.,195, 325-336 .

8. Li X, Zheng S, Agard DA, Cheng Y. (2015) Asynchronous data acquisition and on-the-fly analysis of dose fractionated cryoEM images by UCSFImage. J Struct Biol., 192, 174-178.

9. Chiu PL#, Li X#, Li Z, Beckett B, Brilot AF, Grigorieff N, Agard DA, Cheng Y, Walz T. (2015) Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0. J Struct Biol., 192(2):163-73.

10. Li X, Mooney P, Zheng S, Booth CR, Braunfeld MB, Gubbens S, Agard DA, Cheng Y. (2013) Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM. Nat Methods, 10(6):584-90.