联系方式

电话:+86-10-62786823

邮箱:zhucheng_chen@mail.tsinghua.edu.cn

个人主页

陈柱成 博士

研究员 自然科学资金委杰出青年

个人履历

1994-1998南开大学 学士

1998-2001北京大学 硕士

2001-2003纽约大学 硕士

2003-2008康奈尔大学 博士

2008-2008纪念斯隆-凯特琳癌症中心 博士后

2008-2011德克萨斯大学西南医学中心 博士后

2011-2017清华大学生命科学学院 长聘系列副教授

2017- 至今清华大学生命科学学院 长聘副教授

主要科研领域与方向

我们实验室利用晶体学和电子显微镜学等多种生物物理手段研究重要蛋白质分子机器的工作机理, 尤其是染色质重塑的机理。

代表性论文

1. Liu X, Li M, Xia X, Li X*, Chen Z*. (2017) Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure. Nature, 544 (7651):440-445.

2. Guan R, Zhang L, Su Q P, Mickolajczyk KJ, Chen GY, Hancock WO, Sun Y. Zhao Y, Chen Z*. (2017) Crystal structure of Zen4 in the apo state reveals a missing conformation of kinesin Nature Communication, 8:14951.

3. Yan L, Wang L, Tian Y, Xia X, Chen Z*. (2016) Structure and regulation of the chromatin remodeller ISWI. Nature, 540(7633):466-469.

4. Xu P, Li C, Chen Z, Jiang S, Fan S, Wang J, Dai J, Zhu P*, Chen Z*. (2016) The NuA4 core complex acetylates nucleosomal histone H4 through a double recognition mechanism. Mol. Cell., 63 (6):965-75.

5. Qin Y, Tan C, Lin, J, Qin Q, He J, Wu, Q, Cai Y, Chen Z*, Dai J*. (2016) EcoExpress – a highly efficient construction and expression of multicomponent protein complexes in Escherichia coli. ACS Synth Biol, 5(11):1239-1246.

6. Cao T, Sun L, Jiang Y, Huang S, Wang J, Chen Z*. (2016) Crystal structure of a nuclear actin ternary complex. Proc Natl Acad Sci U S A, 113(32): 8985-90.

7. Xia X, Liu X, Li T, Fang, X, Chen Z*. (2016) Structure of chromatin remodeler Swi2/Snf2 in the resting state. Nat. Struct. Mol. Biol., 23(8):722-9.

8. Xu X, Lin A, Zhou C, Blackwell SR, Zhang Y, Wang Z, Feng Q, Guan R, Hanna MD, Chen Z*, Xiao W*. (2016) Involvement of budding yeast Rad5 in translesion DNA synthesis through physical interaction with Rev1. Nucleic Acids Res, 44(11): 5231-45.

9. Mi N, Chen Y, Wang S, Chen M, Zhao M, Yang G, Ma M, Su Q, Luo S, Shi J, Xu J, Guo Q, Gao N, Sun Y, Chen Z*, Yu L*. (2015) CapZ regulates autophagosomal membrane shaping by promoting actin assembly inside the isolation membrane. Nat Cell Biol. 17(9):1112-23.

10. Sun L, Guan R, Lee IJ, Liu Y, Chen M, Wang J, Wu JQ, Chen Z*. (2015) Mechanistic insights into the anchorage of the contractile ring by anillin and Mid1. Dev Cell., 33(4):413-26.