电话：+86-10-62789401
邮箱：xinquanwang@mail.tsinghua.edu.cn
教授
学术指导委员会成员
2014无锡应用科技生命科学与化学奖
2010中国教育部新世纪人才计划
2010霍英东中国青年教师教育基金会
1990-1995复旦大学 学士
1995-2000中国科学院生物物理研究所 博士
2000-2003中国科学院生物物理研究所 助理研究员
2003-2008斯坦福大学 博士后
2008-2013清华大学生命科学学院 Tenure系列副教授
2013-至今 清华大学生命科学学院 教授
主要研究方向为结构生物学。利用生物大分子及复合物结构测定为主要手段，结合其他生物化学及生物物理技术，研究细胞因子介导的宿主免疫反应和病毒侵染及免疫逃逸的结构机理。
1. Zhang S, Liang Q, He X, Zhao C, Ren W, Yang Z, Wang Z, Ding Q, Deng H, Wang T*, Zhang L*, Wang X*. Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2. Cell Res. (2022) 32(3):315-318.
2. Ge J, Wang R, Ju B, Zhang Q, Sun J, Chen P, Zhang S, Tian Y, Shan S, Cheng L, Zhou B, Song S, Zhao J, Wang H, Shi X, Ding Q, Liu L, Zhao J, Zhang Z*, Wang X*, Zhang L*. (2021) Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry. Nature Communications, 12(1):250.
3.Zhang, S., Qiao, S., Yu, J., Zeng, J. & Wang, X*.(2021). Bat and pangolin coronavirus spike glycoprotein structures provide insights into sars-cov-2 evolution. Nature Communications, 12(1), 1607.
4.Yu J, Qiao S, Guo R & Wang X*. Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution. Nat Commun 11, 3070, doi: 10.1038/s41467-020-16876-4 (2020)
5.Ju B, Zhang Q, Ge J, Wang R, Sun J, Ge X, Yu J, Shan S, Zhou B, Song S, Tang X, Yu J, Lan J, Yuan J, Wang H, Zhao J, Zhang S, Wang Y, Shi X, Liu L, Zhao J, Wang X*, Zhang Z & Zhang L. Human neutralizing antibodies elicited by SARS-CoV-2 infection. Nature. 2020 May 26. doi: 10.1038/s41586-020-2380-z (2020).
6.Lan J, Ge J, Yu J, Shan S, Zhou H, Fan S, Zhang Q, Shi X, Wang Q, Zhang L*, Wang X*.(2020)Structure of the SARS- CoV- 2spikereceptor-bindingdomainbound to the ACE2receptor.Nature, doi: 10.1038/s41586-020-2180-5.
7. Zhou H, Chen Y, Zhang S, Niu P, Qin K, Jia W, Huang B, Zhang S, Lan J, Zhang L, Tan W, Wang X*. (2019) Structural definition of a neutralization epitope on the N-terminal domain of MERS-CoV spikeglycoprotein. Nat Commun., 10(1):3068.
8. Song W, Gui M, Wang X, Xiang Y.Cryo-EM structure of the SARS coronavirus spike glycoprotein in complex with its host cellreceptor ACE2. PLoS Pathog.,14(8):e1007236.
9.Gui M, Song W, Zhou H, Xu J, Chen S, Xiang Y*, Wang X*.(2017) Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell Res., 27(1):119-129.
10.Zuo T, Sun J, Wang G, Jiang L, Zuo Y, Li D, Shi X, Liu X, Fan S, Ren H, Hu H, Sun L, Zhou B, Liang M, Zhou, Paul*, Wang X*, Zhang L*. (2015)Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection. Nature Communications , 6: 8855.
11.Yu X, Zhang S, Jiang L, Cui Y, Li D, Wang D, Wang, N, Fu L, Shi X, Li Z, Zhang L*, Wang X*. (2015)Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27. Scientific Reports, 5:13133.
12.Jiang L, Wang N, Zuo T, Shi X, Poon K, Wu Y, Gao F, Li D, Wang R, Guo J, Fu L, Yuen KY, Zheng B*, Wang X*, Zhang Linqi*.(2014) Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein. Science Translational Medicine , 6 (234):234ra59.
13.Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S*, Wang X*. (2013)Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci USA., 110:14918-23.
14.Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen YH, Zhang L*, Wang X*.(2013) Structure of MERS-CoV spike receptor binding domain complexed with human receptor DPP4. Cell Res., 23: 986-93.
15.Wang D, Huang B, Zhang S, Yu X, Wu W, Wang X*. (2013)Structural basis for R-Spondin recognition by LGR4/5/6 receptors. Genes Dev., 27:1339-44.
