联系方式

电话:+86-10-62789401

传真:+86-10-62792736

邮箱:xinquanwang@mail.tsinghua.edu.cn

王新泉 博士

教授 中心学术指导委员会成员

个人履历

1990-1995复旦大学 学士

1995-2000中国科学院生物物理研究所 博士

2000-2003中国科学院生物物理研究所 助理研究员

2003-2008斯坦福大学 博士后

2008-2013清华大学生命科学学院 Tenure系列副教授

2013- 至今 清华大学生命科学学院 教授

主要科研领域与方向

主要研究方向为结构生物学。利用生物大分子及复合物结构测定为主要手段,结合其他生物化学及生物物理技术,研究细胞因子介导的宿主免疫反应和病毒侵染及免疫逃逸的结构机理。

代表性论文

1. Gui M, Song W, Zhou H, Xu J, Chen S, Xiang Y*, Wang X*.  (2017) Cryo-electron microscopy structures of the SARS-CoV spike glycoprotein reveal a prerequisite conformational state for receptor binding. Cell Res, 27(1):119-129.

2. Zuo T, Sun J, Wang G, Jiang L, Zuo Y, Li D, Shi X, Liu X, Fan S, Ren H, Hu H, Sun L, Zhou B, Liang M, Zhou P*, Wang X*, Zhang L*. (2015) Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection. Nature Communications, 8 (8855).

3. Yu X, Zhang S, Jiang L, Cui Y, Li D, Wang D, Wang, N, Fu L, Shi X, Li Z, Zhang L*, Wang X*. (2015) Structural basis for the neutralization of MERS-CoV by a human monoclonal antibody MERS-27. Scientific Report, 5 (13133).

4. Jiang L, Wang N, Zuo T, Shi X, Poon K, Wu Y, Gao F, Li D, Wang R, Guo J, Fu L, Yuen KY, Zheng B*,  Wang X*, Zhang Linqi*. (2014)  Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein. Science Translational Medicine, 6 (234).

5. Liu X, Hammel M, He Y, Tainer JA, Jeng US, Zhang L, Wang S*, Wang X*. (2013) Structural insights into the interaction of IL-33 with its receptors. Proc Natl Acad Sci U S A, 110:14918-23.

6. Wang N, Shi X, Jiang L, Zhang S, Wang D, Tong P, Guo D, Fu L, Cui Y, Liu X, Arledge KC, Chen YH, Zhang L*, Wang X*. (2013)  Structure of MERS-CoV spike receptorbinding domain complexed with human receptor DPP4. Cell Res, 23: 986-93.

7. Wang D, Huang B, Zhang S, Yu X, Wu W, Wang X. (2013) Structural basis for R-Spondin recognition by LGR4/5/6 receptors. Genes Dev, 27:1339-44.

8. Luan X, Lu Q, Jiang Y, Zhang S, Wang Q, Yuan H, Zhao W, Wang J, Wang X. (2012) Crystal structure of human RANKL complexed with its decoy receptor osteoprotegerin. J Immunol., 189 (1):245-52.

9. Xue X, Lu Q, Wei H, Wang D, Chen D, He G, Huang L, Wang H, Wang X. (2011) Structural basis of chemokine sequestration by CrmD, a poxvirus-encoded tumor necrosis factor receptor. PLoS Pathog.,7 (7):e1002162.

10. Wang D, Zhang S, Li L, Liu X, Mei K, Wang X. (2010) Structural insights into the assembly and activation of IL-1β with its receptors. Nat Immunol, 11(10):905-11.