联系方式

电话:010-627-88745

邮箱:qhtaolab@mail.tsinghua.edu.cn

陶庆华 教授

入选2018年度中国科协生命科学十大进展
清华大学生命科学学院2018年度(首届)科学技术突破奖

个人履历

1988-1992四川大学生物工程系遗传学专业 学士

1995-2000中科院上海细胞所发育生物学专业 博士

2000-2008美国俄亥俄州辛辛那提市儿童医院发育生物学系 博士后 研究助理

2008-至今 清华大学生命科学学院 教授

主要科研领域与方向

本实验室综合运用基因组学、蛋白质组学、分子生物学、遗传学等技术,研究脊椎胚胎早期发育中的细胞命运决定和分化的分子机理,尤其是储备在卵母细胞中的mRNA、蛋白、小分子等母源因子的作用。

研究方向:

1、 母源背方决定因子Huluwa与Wnt/β-catenin信号的互作机理及其在Spemann organizer生成中的作用

2、 母源因子调控胚层前体细胞决定与分化的机制

3、 母源因子在胚胎细胞神经命运决定和分化中的作用

代表性论文

1. Yan L#, Chen J#, Zhu XC#, Sun JW, Wu XT, Shen WM, Zhang WY, Tao QH*, Meng AM* (2018) Maternal Huluwa Dictates the Embryonic Body Axis through b-catenin in Vertebrates. Science 362(6417). pii: eaat1045. doi: 10.1126/science.aat1045. (* Co-correspondence authors).

2. Lin H1#, Zhu XC1#, Chen G1, Song L1, Gao L1, Khand AA1, Chen Y2, Lin GF2*, Tao QH1* (2017) KDM3A-mediated dimethylation of histone H3 lysine 9 facilitates the chromatin binding of Neurog2 during neurogenesis. Development 144(20): 3674-3685. (*Correspondence author).

3. Gao L, Zhu XC, Chen G, Ma X, Zhang Y, Khand A, Shi H, Gu F, Lin H, Chen Y, Zhang H, He L, Tao QH* (2016) A novel role for Ascl1 in the regulation of mesendoderm formation via HDAC-dependent antagonism of VegT function. Development 143(3):492-503. (*Correspondence author).

4. Lin H, Min Z, Tao QH* (2016) The MLL/Setd1b methyltransferase is required for the Spemann’s organizer gene activation in Xenopus. Mech. Dev. 142:1-9.

5. Sun G, Hu Z, Min Z, Yan X, Guan Z, Su H, Fu Y, Ma X, Chen YG, Zhang MQ*, Tao QH*, Wu W* (2015) Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor β (TGFβ)-mediated Germ Layer Induction in Xenopus Embryos. J. Biol. Chem. 290(28):17239-49. (* co-correspondence authors).

6. Zhang Y, Ding Y, Chen YG*, Tao QH* (2014) NEDD4L regulates convergent extension movements in Xenopus embryos via Dishevelled-mediated non-canonical Wnt signaling. Dev. Biol.  392(2014): 15-25. (* Co-correspondence authors).

7. Ding Y, Zhang Y, Xu C, Tao QH* and Chen YG* (2013) HECT Domain-containing E3 ubiquitin ligase NEDD4L negatively regulates Wnt signaling by targeting Dishevelled for proteasomal degradation. J. Biol. Chem. 288, 8289-98. (* Co-correspondence authors).

8. Tao QH, Yokota C, Puck H, Kofron M, Birsoy B, Dong Y, Asashima M, Wylie C, Lin X and Heasman J. (2005a). Maternal Wnt11 activates the canonical Wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120:857-871.