联系方式

电话:86-10-62788131

邮箱:zhanglinqi@tsinghua.edu.cn

张林琦 博士

教授
2007 “新世纪百千万人才工程”国家级人选
2007 科技部“973”计划首席科学家
2008 国家自然科学基金杰出青年基金
2015 国家科技进步奖二等奖
2015 “十一五”到“十三五”国家科技重大专项艾滋病粘膜疫苗首席科学家
2016 清华大学教育教学成果一等奖
2016 连续三年爱思唯尔中国高被引学者感染和免疫专业第一名
2016 当选为非洲科学院院士

个人履历

1981-1985 北京师范大学生物系 学士

1988-1993 英国爱丁堡大学分子遗传学系 博士、博士后

1993-1997 美国纽约大学 博士后

1997-2007 美国洛克菲勒大学 助理教授、副教授

2011-2013 清华大学医学院基础医学 系主任

2013-2016 清华大学医学院 副院长

2007- 至今 清华大学医学院教授 北京协和医学院兼职教授 清华大学艾滋病综合研究中心主任 全球健康与传染病研究中心主任

主要科研领域与方向

艾滋病等人类重大病毒性传染病的致病机理。重点研究疾病进展过程中病毒与免疫系统相互作用关系,研发抗病毒药物、抗体和疫苗。通过解析多克隆和单克隆抗体的结构和功能,综合分析人体保护性抗体反应的组成特点,并利用结构生物学和系统生物学手段,理性设计优化单克隆抗体和疫苗,力争率先研发成功根治艾滋病的治疗策略和高效艾滋病疫苗。在研的其它方向还包括中东呼吸道冠状病毒,埃博拉病毒,寨卡病毒和禽流感病毒等新发突发高致病性病毒。

代表性论文

1.Zhou P, Wang H, Fang M, Li Y, Wang H, Shi S, Li Z, Wu J, Han X, Shi X, Shang H, Zhou T, Zhang L. 2019. Broadly resistant HIV-1 against CD4-binding site neutralizing antibodies. PLoS Pathog 15:e1007819.

2.Wang Q, Liu L, Ren W, Gettie A, Wang H, Liang Q, Shi X, Montefiori DC, Zhou T, Zhang L. 2019. A Single Substitution in gp41 Modulates the Neutralization Profile of SHIV during In Vivo Adaptation. Cell Rep 27:2593-2607.e5.

3.Wang L, Wang R, Wang L, Ben H, Yu L, Gao F, Shi X, Yin C, Zhang F, Xiang Y, Zhang L. 2019. Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody. Cell Rep 26:3360-3368.e5.

4.Li G, Jiang Y, Zhang L. 2019. HIV upsurge in China's students. Science 364:711.

5.Jia W, Channappanavar R, Zhang C, Li M, Zhou H, Zhang S, Zhou P, Xu J, Shan S, Shi X, Wang X, Zhao J, Zhou D, Perlman S, Zhang L. 2019. Single intranasal immunization with chimpanzee adenovirus-based vaccine induces sustained and protective immunity against MERS-CoV infection. Emerg Microbes Infect 8:760-772.

6.Zuo Y, Wang P, Sun J, Guo S, Wang G, Zuo T, Fan S, Zhou P, Liang M, Shi X, Wang X, Zhang L. 2018. Complementary recognition of the receptor-binding site of highly pathogenic H5N1 influenza viruses by two human neutralizing antibodies. J Biol Chem 293:16503-16517.

7.Zhang S, Zhou P, Wang P, Li Y, Jiang L, Jia W, Wang H, Fan A, Wang D, Shi X, Fang X, Hammel M, Wang S, Wang X, Zhang L. 2018. Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein. Cell Rep 24:441-452.

8.Wang H, Chen X, Wang D, Yao C, Wang Q, Xie J, Shi X, Xiang Y, Liu W, Zhang L. 2018. Epitope-focused immunogens against the CD4-binding site of HIV-1 envelope protein induce neutralizing antibodies against auto- and heterologous viruses. J Biol Chem 293:830-846.

9.Li C, Gao F, Yu L, Wang R, Jiang Y, Shi X, Yin C, Tang X, Zhang F, Xu Z, Zhang L. 2018. A Single Injection of Human Neutralizing Antibody Protects against Zika Virus Infection and Microcephaly in Developing Mouse Embryos. Cell Rep 23:1424-1434.

10.Zhang Q, Gui M, Niu X, He S, Wang R, Feng Y, Kroeker A, Zuo Y, Wang H, Wang Y, Li J, Li C, Shi Y, Shi X, Gao GF, Xiang Y, Qiu X, Chen L, Zhang L. 2016. Potent neutralizing monoclonal antibodies against Ebola virus infection. Sci Rep 6:25856.

11.Jin S, Ji Y, Wang Q, Wang H, Shi X, Han X, Zhou T, Shang H, Zhang L. 2016. Spatiotemporal hierarchy in antibody recognition against transmitted HIV-1 envelope glycoprotein during natural infection. Retrovirology 13:12.

12.Zuo T, Sun J, Wang G, Jiang L, Zuo Y, Li D, Shi X, Liu X, Fan S, Ren H, Hu H, Sun L, Zhou B, Liang M, Zhou P, Wang X, Zhang L. 2015. Comprehensive analysis of antibody recognition in convalescent humans from highly pathogenic avian influenza H5N1 infection. Nat Commun 6:8855.

13.Jiang L, Wang N, Zuo T, Shi X, Poon KM, Wu Y, Gao F, Li D, Wang R, Guo J, Fu L, Yuen KY, Zheng BJ, Wang X, Zhang L. 2014. Potent Neutralization of MERS-CoV by Human Neutralizing Monoclonal Antibodies to the Viral Spike Glycoprotein. Sci Transl Med 6:234ra59.