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电话:021-54923161

龙钢 博士

研究员
2002年中国科学院院长奖学金,中国科学院武汉病毒研究所
2006年玛丽居里奖学金,海德堡大学医学院

个人履历

1995–1999 南昌大学 学士

1999–2002 中国科学院武汉病毒所 硕士

2002–2006 瓦赫宁恩大学 博士

2003-2007 中国科学院武汉病毒研究所 助理研究员

2007-2012 海德堡大学医学院 博士后

2013-至今 中国科学院上海巴斯徳研究所 研究员

主要科研领域与方向

主要从事肝炎病毒,虫媒脑炎病毒等为对象的分子病毒学研究。重点关注肝炎脑炎等病毒的感染性病毒颗粒的组装以及非保守性组装机制,病毒感染的活细胞示踪工具开发和神经环路示踪应用。同时以病毒为研究对象,研究外泌体组装和释放平衡的细胞生物学机制。

代表性论文

1.Deng L, Jiang W, Wang X, Merz A, Hiet MS, Chen Y, Pan X, Jiu Y, Yang Y, Yu B, He Y, Tu Z, Niu J, Bartenschlager R, Long G. Syntenin regulates hepatitis C virus sensitivity to neutralizing antibody by promoting E2 secretion through exosomes. J Hepatol. 2019 Mar 15 (19)30147-3.

2.Bian WX, Xie Y, Wang XN, Xu GH, Fu BS, Li S, Long G, Zhou X, Zhang XL. Binding of cellular nucleolin with the viral core RNA G-quadruplex structure suppresses HCV replication. Nucleic Acids Res. 2019 Jan 10; 47(1):56-68.

3.Zhao F, Xu Y, Lavillette D, Zhong J, Zou G, Long G. Negligible contribution of M2634V substitution to ZIKV pathogenesis in AG6 mice revealed by a bacterial promoter activity reduced infectious clone. Sci Rep. 2018 Jul 12; 8(1):10491.

4.Jiang W, Muhammad F, Ma P, Liu X, Long G. Sofosbuvir inhibits hepatitis A virus replication in vitro assessed by a cell-based fluorescent reporter system. Antiviral Res. 2018 Jun;154:51-57. doi: 10.1016

5.Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, Zhang Y, Lin X, Gao X, Xu A, Li Y. Hepatic CREBZF couples insulin to lipogenesis by inhibiting insig activity and contributes to hepatic steatosis in diet-induced insulin-resistant mice. Hepatology. 2018 Oct;68(4):1361-1375.

6.Levander S, Holmström F, Frelin L, Ahlén G, Rupp D, Long G, Bartenschlager R, Sällberg M. Immune-mediated effects targeting hepatitis C virus in a syngeneic replicon cell transplantation mouse model. Gut. 2018 Aug; 67(8):1525-1535.

7.Zhao F, Zhao T, Deng L, Lv D, Zhang X, Pan X, Xu J, Long G. Visualizing the Essential Role of Complete Virion Assembly Machinery in Efficient Hepatitis C Virus Cell-to-Cell Transmission by a Viral Infection-Activated Split-Intein-Mediated Reporter System. J Virol. 2017 Jan 3; 91(2):1720-16.

8.Yang Z, Wang X, Chi X, Zhao F, Guo J, Ma P, Zhong J, Niu J, Pan X, Long G. Neglected but Important Role of Apolipoprotein E Exchange in Hepatitis C Virus Infection. J Virol. 2016 Oct 14; 90(21):9632-9643.

9.Long G, Hiet MS, Windisch MP, Lee JY, Lohmann V, Bartenschlager R. 2011. Mouse hepatic cells support assembly of infectious hepatitis C virus particles. Gastroenterology, 141(3):1057-66.

10.Merz A*, Long G*, Hiet MS, Brügger B, Chlanda P, Andre P, Wieland F, Krijnse-Locker J, Bartenschlager R. 2011. Biochemical and Morphological properties of hepatitis C virus particles and determination of their lipidome. J. Biol. Chem. 286(4): 3018-3032. *co-first authors.