联系方式

邮箱:E-mail: lliu@mail.tsinghua.edu.cn

刘磊

个人履历

1995-1999 中国科学技术大学 学士

1999-2004 哥伦比亚大学 博士

2004-2007 美国斯克利普斯研究所 博士后

2007-至今 清华大学化学系 教授

主要科研领域与方向

蛋白质化学合成

代表性论文

1. Tang S, Liang LJ, Si YY, Gao S, Wang JX, Liang J, Mei Z, Zheng JS, Liu L.(2017) Practical chemical synthesis of atypical ubiquitin chains by using an isopeptide linked Ub isomer. Angew. Chem. Int. Ed., 56, 13333.

2. Tang S, Zuo C, Huang DL, Cai XY, Zhang LH, Tian CL, Zheng JS, Liu L. (2017) Chemical synthesis of membrane proteins by the removable backbone modification method. Nature Protocols, 12, 2554.

3. Tang S, Zuo C, Huang DL, Cai XY, Zhang LH, Tian CL, Zheng JS, Liu L. (2017) Removable backbone modification method for the chemical synthesis of membrane proteins. Acc. Chem. Res., 50, 1143.

4. Li YT, Yi C, Chen CC, Lan H, Pan M, Zhang SJ, Huang YC, Guan CJ, Li YM, Yu L, Liu L. (2017) A semisynthetic Atg3 reveals that acetylation promotes Atg3 membrane binding and Atg8 lipidation. Nature Commun., 8, 14846.

5. Gao S, Pan M, Zheng Y, Huang Y, Zheng Q, Sun D, Lu L, Tan X, Tan X, Lan H, Wang J, Wang T, Wang J, Liu L. (2016) Monomer/oligomer quasi-racemic protein crystallography. J. Am. Chem. Soc., 138, 14497.

6. Pan M, Gao S, Zheng Y, Tan X, Lan H, Tan X, Sun D, Lu L, Wang T, Zheng Q, Huang Y, Wang J, Liu L. (2016) Quasi-racemic X-ray structures of K27-linked ubiquitin chains prepared by total chemical synthesis. J. Am. Chem. Soc., 138, 7429.

7. Wang Z, Xu W, Liu L, Zhu TF. (2016) A synthetic molecular system capable of mirror-image genetic replication and transcription. Nature Chem., 8, 698.

8. Zheng JS, He Y, Zuo C, Cai XY, Tang S, Wang ZA, Zhang LH, Tian CL, Liu L. (2016) Robust chemical synthesis of membrane proteins through a general method of removable backbone modification. J. Am. Chem. Soc., 138, 3553.

9. Wang J, Tang S, Wan Z, Gao Y, Cao Y, Yi J, Si Y, Zhang H, Liu L, Liu W. (2016) Utilization of a photoactivatable antigen system to examine B cell probing termination and the B cell receptor sorting mechanisms during B cell activation. Proc. Natl. Acad. Sci. USA, 113, E558.