联系方式

电话:+86-10-62797560

传真:+86-10-62792736

邮箱:shi-lab@mail.tsinghua.edu.cn

个人主页

Yigong Shi Ph.D.

Professor | Outstanding Young Talent of National Science Foundation For China | Academician of the Chinese Academy of Sciences | Foreign Associate of the US National Academy of Sciences | Honorary Foreign Member of the American Academy of Arts and Sciences | Chairman of ICSB Executive Committee

个人履历

1985-1989Department of Biological Sciences and Biotechnology, Tsinghua University B.S.

1990-1995The Johns Hopkins University School of Medicine Ph.D.

1995-1996The Johns Hopkins Univercity School of Medicine Postdoc.

1996-1997Memorial Sloan-Kettering Cancer Center Postdoc.

1998-2001Department of Molecular Biology, Princeton University Assistant Professor

2001-2003Department of Molecular Biology, Princeton University Associate Professor

2003-2008Department of Molecular Biology, Princeton University Professor

2007-2008Department of Molecular Biology, Princeton University Warner-Lambert/Parke-Davis Professor

2008-PresentSchool of Life Sciences, Tsinghua University Professor

主要科研领域与方向

We combine structural biology and biochemistry to elucidate the molecular mechanisms of fundamental cellular events, with a focus on apoptosis, regulated intramembrane proteolysis related to Alzheimer’s disease, and pre-mRNA splicing.

代表性论文

1. Zhan X, Yan C*, Zhang X, Lei J, Shi Y*. (2018) Structure of a human catalytic step I spliceosome. Science, 359(6375):537-545.

2. Bai R, Yan C, Wan R, Lei J, Shi Y. (2017) Structure of the Post-catalytic Spliceosome from Saccharomyces cerevisiae. Cell, 171(7):1589-1598.

3. Wan R, Yan C, Bai R, Lei J, Shi Y. (2017) Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiae. Cell, 171(1):120-132.

4. Zhang X, Yan C*, Hang J, Finci LI, Lei J, Shi Y*. (2017) An Atomic Structure of the Human Spliceosome. Cell, 169(5):918-929.

5. Yan C, Wan R, Bai R, Huang G, Shi Y. (2017) Structure of a yeast step II catalytically activated spliceosome. Science, 355(6321):149-155.

6. Wan R, Yan C, Bai R, Huang G, Shi Y. (2016) Structure of a yeast catalytic step I spliceosome at 3.4 Å resolution. Science, 353(6302):895-904.

7. Yan C, Wan R, Bai R, Huang G, Shi Y. (2016) Structure of a yeast activated spliceosome at 3.5 Å resolution. Science, 353(6302):904-11.

8. Wan R, Yan C, Bai R, Wang L, Huang M, Wong CC, Shi Y. (2016) The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis. Science, 351(6272):466-75.

9. Yan C, Hang J, Wan R, Huang M, Wong CC, Shi Y. (2015) Structure of a yeast spliceosome at 3.6-angstrom resolution. Science, 349(6253):1182-91.

10. Hang J, Wan R, Yan C, Shi Y. (2015) Structural basis of pre-mRNA splicing. Science, 349(6253):1191-8.

11. Bai XC*, Yan C, Yang G, Lu P, Ma D, Sun L, Zhou R, Scheres SHW*, Shi Y*. (2015) An atomic structure of human γ-secretase. Nature, 525(7568):212-217.

12. Lu P, Bai XC, Ma D, Xie T, Yan C, Sun L, Yang G, Zhao Y, Zhou R, Scheres SHW*, Shi Y*. (2014) Three-dimensional structure of human γ-secretase. Nature,512(7513):166-170.