联系方式

衡杰 博士

个人履历

2006-2010四川农业大学 学士

2010-2015中国科学院生物物理研究所 博士

2015-至今清华大学医学院 博士后

主要科研领域与方向

结合多维互补的生物物理学技术,包括单分子荧光共振能量转移,溶液核磁共振,顺磁弛豫增强等,研究G蛋白偶联受体及其下游的多个信号传递复合物(G蛋白/G蛋白偶联受体激酶/Arrestin)的结构动态及功能调控机理。

代表性论文

1. Heng J, Zhao Y, Liu M, Liu Y, Fan J, Wang X, Zhao Y, and Zhang X C. (2015) Substrate-bound structure of the E. coli multidrug resistance transporter MdfA. Cell research. 25, 1060-1073

2. Zhang, X.C., Zhao, Y., Heng, J., and Jiang, D. (2015). Energy coupling mechanisms of MFS transporters. Protein Sci. 24, 1560–1579.

3. Jiang, D., Zhao, Y., Wang, X., Fan, J., Heng, J., Liu, X., Feng, W., Kang, X., Huang, B., Liu, J., et al. (2013). Structure of the YajR transporter suggests a transport mechanism based on the conserved motif A. Proc. Natl. Acad. Sci. 110, 14664–14669.

4. Fan, J., Heng, J., Dai, S., Shaw, N., Zhou, B., Huang, B., He, Z., Wang, Y., Jiang, T., Li, X., et al. (2011). An efficient strategy for high throughput screening of recombinant integral membrane protein expression and stability. Protein Expression and Purification 78, 6–13.