视频资料

Video material

宣传视频科普视频其他视频
2019/06/04

γ-secretase

阿尔兹海默症(老年痴呆症,简称AD)是老年人中最常见的失智症。 Alzheimer's disease (AD) is the most common form of dementia in the elder population. 0’12-0’17(字幕2) 该病会逐步加重,最终摧毁病人的记忆及其他神经功能。 It is a progressive disease that destroys memory and other important mental functions. 0’17-0’21(字幕3) 每三秒钟,全球就有一例AD病人产生。 Every 3 seconds, someone in the world develops the disease. 0’22-0’28(字幕4) 据估计,到2050年全球可能有近1.3亿的AD病人。 The estimated number of inflicted patients will reach more than 130 million by 2050. 0’29-0’37(字幕5) 然而,现有药物只能局部减轻病人痛苦,目前仍然没有一项治疗措施能够停止或逆转疾病进程。 However, until now, no treatments stop or reverse its progression, though some may temporarily improve symptoms. 0’38-0’45(字幕6) 伽马分泌酶是一种膜内蛋白水解酶,被认为是AD发病机制中的关键一环。 Gamma secretase is an intramembrane protease, which plays an important role in the pathogenesis of Alzheimer’s disease. 0’46-0’50(字幕7) 成熟的伽马分泌酶有四个组份:早老素presenilin,pen-2,nicastrin和APH-1。 A mature -secretase consists of four components: presenilin, pen-2, nicastrin, and APH-1. 1’02-1’07(字幕8) 在四者中,早老素是负责蛋白水解活性的核心部件。 Among these components, presenilin is responsible for the proteolytic activity. 1’09-1’18 疾病突变集中在两个热点区域,分别包括穿膜螺旋2到5,以及穿膜螺旋6到9。 Two disease mutational hospots, are mapped to the inner core of TM(transmembrane)2-5 and inner core of TM(transmembrane) 6-9, respectively. 1’19-1’32 两个负责催化的天冬氨酸残基Asp 257和Asp385分别在穿膜螺旋6和7上。 The two catalytic residues, Aspartic acid 257 and Aspartic acid 385, are located in TM6 and TM7, respectively. 1’32-1’39(字幕10) Pen-2,是伽马分泌酶中最小的组份,和早老素紧密相互作用。 Pen-2, the smallest component of -secretase, closely associates with PS1. 1’42-1’46(字幕11) Nicastrin,是一个具有单次跨膜含有巨大胞外区的蛋白。 Nicastrin, a single transmembrane protein with a large extracellular domain. 四者合一,构成了成熟的伽马分泌酶, Together, the fower components assemble into a mature -secretase 1’53-1’59(字幕12) 在穿膜区形成了一头大,一头小的马蹄状结构域。 Form a horseshoe shaped transmembrane domain, with both a thin and a thick end. 1’59-2’07(字幕13) 最后,7次穿膜螺旋的APH1蛋白具有崭新的折叠方式。 Finally, t

VIEW