Contact information

Pujuan Deng Ph.D.

2019 National Scholarship
2019 Baosteel Education Award
2020 The outstanding graduate of Beijing
2020 “Academic Youngsters”of Tsinghua University

Resume

2011-2015School of Life Sciences, Nanchang University B.S.

2015-2020School of Life Sciences, Beijing Normal University Ph.D.

2020-PresentSchool of Life Sciences, Tsinghua University Postdoc

Main Reaearch Fields

Molecular mechanisms and applications of novel nucleic acid manipulation tool. Currently, it is very inefficient to achieve gene-specific insertion based on the traditional CRISPR system. Therefore, I want to solve structures of the tool in order to understand the molecular mechanisms by cryo-EM, and combine multidisciplinary methods to develop its multi-functional applications.

Selected Publications

1. Deng, P.*, Zhou, Y.*, Jiang, J., Li, H., Tian, W., Cao, Y., ... & Wang, Z. (2018). Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology. PNAS, 115(40), 9998-10003. (* equal contributions)

2. Li, W.*, Tian, W.*, Yuan, G.*, Deng, P.*, ... &Wang, Z. (2020). Structural basis of nucleosome engagement and histone H3 lysine 36 methylation by NSD methyltransferases. Nature. (* equal contributions) in press