Wei Wu Ph.D.

Main Research Fields

Adult stem cells maintain tissue homeostasis via proliferation and differentiation, and, may lead to tumor development when driver mutations accumulate. Using mice and organoid culture technology, combined with chemical biology methods, we study the epigenetic mechanisms underline the differentiation or tumorigenesis of intestinal stem cells, and hope to identify potential therapeutic targeting approaches.

Selected Publications

1.Su S, Yang Z, Gao H, Yang H, Zhu S, An Z, Wang J, Li Q, Chandarlapaty S, Deng H, Wu W*, Rao Y*. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 22;62(16):7575-7582.

2.Zhu G, Fan Z, Ding M, Zhang H, Mu L, Ding Y, Zhang Y, Jia B, Chen L, Chang Z, Wu W. An EGFR/PI3K/AKT axis promotes accumulation of the Rac1-GEF Tiam1 that is critical in EGFR-driven tumorigenesis. Oncogene. 2015 Mar 9.

3.Ding Y, Su S, Tang W, Zhang X, Chen S, Zhu G, Liang J, Wei W, Guo Y, Liu L, Chen YG, Wu W. Enrichment of the β-catenin-TCF complex at the S and G2 phases ensures cell survival and cell cycle progression. J Cell Sci. 2014 Nov 15;127(22):4833-45.

4.Su X, Zhu G, Ding X, Lee SY, Dou Y, Zhu B, Wu W*, and Li H*. Molecular basis underlyinghistone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1. Genes Dev. 2014 Mar 15;28(6):622-36.

5.Fu Y, Huang B, Shi Z, Han J, Wang Y, Huangfu J, Wu W. SRSF1 and SRSF9 RNA binding proteins promote Wnt signaling-mediated tumorigenesis by enhancing β-catenin biosynthesis. EMBO Mol Med. 2013 May;5(5):737-50.

6.Zhu G, Wang Y, Huang B, Liang J, Ding Y, Xu A, Wu W. A Rac1/PAK1 cascade controls β-catenin activation in colon cancer cells. Oncogene. 2012 Feb 23;31(8):1001-

7.Liang J, Fu Y, Cruciat CM, Jia S, Wang Y, Tong Z, Tao Q, Ingelfinger D, Boutros M, Meng A, Niehrs C, Wu W. Transmembrane Protein 198 Promotes LRP6 Phosphorylation and Wnt Signaling Activation. Mol Cell Biol. 2011 Jul;31(13):2577-90.

8.*Davidson G, *Wu W, Shen J, Bilic J, Fenger U, Stannek P, Glinka A, Niehrs C. Casein kinase 1 gamma couples Wnt receptor activation to cytoplasmic signal transduction. Nature. 2005 Dec 8;438(7069):867-72. (*equal contribution)

9.Kazanskaya O, Glinka A, del Barco Barrantes I, Stannek P, Niehrs C, Wu W. Rspo2 is a secreted activator of Wnt/β-catenin signalling and is required for Xenopus myogenesis. Dev Cell. 2004 Oct; 7(4): 525-34.

10.*Mao B, *Wu W, Li Y, Hoppe D, Stannek P, Glinka A, Niehrs C. LDL-receptor-related protein 6 is a receptor for Dickkopf proteins. Nature. 2001 May 17; 411(6835):321-5. (*equal contribution)