Ji Chen Ph.D.

2016 Advanced Innovation Fellow, Beijing Advanced Innovation Center for Structural Biology, Beijing, China
2015 Bird Stair Research Fellowship, Department of Biochemistry, Purdue University, West Lafayette, IN
2015 The New England BioLabs Poster Prize, The 20th Annual Meeting of the RNA Society, Madison, WI
2013 Henry Moses Award, Department of Biochemistry, Purdue University, West Lafayette, IN

Main Research Fields

Discovery, application and structure-based design of functional RNA/DNA molecules.

Selected Publications

1. Chen, J., Manuel, G., Chamberlain, R., Luptak, A., and Golden, B. L.Engineering a ribozyme with tRNA synthetase activity. Manuscript in prep

2. Jiang, W.; Zhang, B.; Fan, C.; Wang, M.; Wang, J.; Deng, Q.; Liu, X.; Chen, J.;Zheng, J.; Liu, L.; Zhu, T. F., Mirror-image polymerase chain reaction. Cell Discovery (2017) 3, 17037.

3. Xu, W.; Jiang, W.; Wang, J.; Yu, L.; Chen, J.; Liu, X.; Liu, L.; Zhu, T. F., Total chemical synthesis of a thermostable enzyme capable of polymerase chain reaction. Cell Discovery (2017) 3, 17008.

4. Mir, A. *; Chen, J. *; Robinson, K.; Lendy, E.; Goodman, J.; Neau, D.; and Golden, B. L. Two divalent metal ions and conformational changes play roles inthe hammerhead ribozyme cleavage reaction. Biochemistry (2015) 54, 6369.(*equal contribution)

5. Chen, J.; Ganguly, A.; Miswan, Z.; Hammes-Schiffer, S.; Bevilacqua, P. C. and Golden, B. L. Identification of the catalytic Mg2+ ion in the hepatitis delta virus ribozyme. Biochemistry (2013) 52, 557.