Contact information

Ruixue Wan Ph.D.

2018 Science & SciLifeLab Prize for Young Scientists
2018 Awards of the Dimitris N.Chorafas Foundation
2018 Advanced Innovation Fellow, Beijing Advanced Innovation Center
for Structural Biology
2018 Finalist of “the National Postdoctoral Program for Innovative Talents”
2016 Finalist of “Future Female Scientists Program”

Resume

2009-2013School of Marine Sciences, Sun Yat-sen University B.S.

2013-2018School of Medicine, Tsinghua University Ph.D.

2018-PresentSchool of Medicine, Tsinghua University Postdoc.

Main Research Fields

Structural and Mechanistic Investigations of the spliceosome.

Selected Publications

1.Ruixue Wan*, Chuangye Yan*, Rui Bai, Lin Wang, Min Huang, Catherine C. L. Wong, & Yigong Shi. The 3.8 ⼠structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis. Science, 2016, 351(6272):466-475.

2.Ruixue Wan*, Chuangye Yan*, Rui Bai*, Gaoxingyu Huang*, & Yigong Shi. Structure of a yeast catalytic step I spliceosome at 3.4-angstrom resolution. Science, 2016, 353(6302):895-904.

3.Ruixue Wan*, Chuangye Yan*, Rui Bai*, Jianlin Lei, & Yigong Shi. Structure of an intron lariat spliceosome from Saccharomyces cerevisiae. Cell, 2017, 171, 120-132.

4.Rui Bai*, Ruixue Wan*, Chuangye Yan*, Jianlin Lei, & Yigong Shi. Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activation. Science, 2018, 360(6396):1423-1429.

5.Jing Hang*, Ruixue Wan*, Chuangye Yan*, & Yigong Shi. Structural basis of pre-mRNA splicing. Science, 2015, 349(6253):1191-1198.