Yi Xue_Beijing Frontier Research Center for Biological Structure

Contact information

Email：yixue@mail.tsinghua.edu.cn

Yi Xue Ph.D.

Assistant Professor

Resume

1993-1997Modern Applied Physics, Tsinghua University B.S.

1997-1999Start Computer Company Engineer

2000-2003Biological Science and Biotechnology, Tsinghua University M.S.

2004-2009Department of Chemistry, Purdue University Ph.D.

2010-2013Department of Chemistry, Purdue University Postdoc.

2013-2016University of Michigan; Duke University Postdoc.

2016-PresentSchool of Life Sciences, Tsinghua University Assistant Professor

Main Research Fields

Our primary research interests are focused on characterizing structure and dynamics of non-coding RNAs and intrinsically disordered proteins using solution NMR spectroscopy and computational approaches such as MD simulations. We aim to develop novel NMR techniques, labeling methods, and computational tools to study three-dimensional structure and conformational switch of large non-coding RNAs and ribonucleoproteins, which pose a significant challenge to existing methods. We are also interested in reconstructing conformational motion of highly flexible biomolecules, as well as ensemble-based virtual drug screening.

Selected Publications

1. Han, G. and Xue, Y.# (2022). Rational design of hairpin RNA excited states reveals multi-step transitions. Nat. Commun. 13, 1523
2. Cao, J. and Xue, Y.# (2021). Characteristic chemical probing patterns of loop motifs improve prediction accuracy of RNA secondary structures. Nucleic Acids Res. 49, 4294-4307
3. Wang, Y., Han, G., Jiang, X., Yuwen, T. and Xue, Y.# (2021). Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states. Nat. Commun. 12, 1595
4. Li, W., Kou, J., Qin, J., Li, L., Zhang, Z., Pan, Y., Xue, Y.# and Du, W.# (2021). NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex. Nat. Metab. 3, 75-89
5. Song, Y., Zhang, Y., Pan, Y., He, J., Wang, Y., Chen, W., Guo, J., Deng, H., Xue, Y.#, Fang, X.# and Liang, X.# (2020). The microtubule end-binding affinity of EB1 is enhanced by a dimeric organization that is susceptible to phosphorylation. J. Cell Sci. 133, jcs241216

About us

Faculty

Research

News&Events

Meeting

Download

Contact Us