Contact information

Email:lixueming@mail.tsinghua.edu.cn

Xueming Li Ph.D.

Associate Professor | FRCBS Executive Committee Member

Resume

1998-2002University of Science and Technology Beijing B.S.

2002-2005University of Science and Technology Beijing M.S.

2005-2009Institute of Physics, CAS Ph.D.

2009-2013University of California, San Francisco Postdoc.

2014-2017School of Life Science, Tsinghua University Assistant professor

2017-2019School of Life Science, Tsinghua University Associate professor

2014-PresentSchool of Life Science, Tsinghua University Assistant professor (Tenured)

Main Reaearch Fields

We focus on the theoretical and methodological development of electron cryo-microscopy(CryoEM) and its application in structural biology to address important biological questions. We are particularly interested in developing and applying novel image processing technology to advance CryoEM for routine atomic-resolution structure analysis of biological macromolecules. In biology, we are working on the structural and functional mechanism of bacterial secretion system.

Selected Publications

1. Xinyu Zhang#, Tianfang Zhao#, Jian Chen, Yuan Shen, Xueming Li*.(2022) Epicker is an exemplar-based continual learning approach for knowledge accumulation in cryoEM particle picking. Nature Communication, 2022.13(1):2468
2. Xuzhong Yang#, Chao Lin#, Xudong Chen#, Shouqin Li#, Xueming Li, Bailong Xiao.(2022) Structure deformation and curvature sensing of PIEZO1 in lipid membranes. Nature, 604(7905);377-383.
3. Meijing Li#, Jianfei Ma#, Xueming Li*, Sen-Fang Sui*, In situ cryo-ET structure of phycobilisome - photosystem II supercomplex from red alga, ELife, 2021, 10, e69635.
4. Mingxu Hu#, Qi Zhang#, Jing Yang*, Xueming Li*,Unit quaternion description of spatial rotations in 3D electron cryo-microscopy, Journal of Structural Biology, 2020, 212, 107601
5. Zhaofeng Yan, Meng Yin, Jianan Chen, Xueming Li*.(2020) Assembly and Substrate Recognition of Curli Biogenesis System. Nature Communication, 2020, 11(1), 241.
6. Li Wang, Heng Zhou, Mingmin Zhang, Wenhao Liu, Tuan Deng, Qiancheng Zhao, Yiran Li, Jianlin Lei, Xueming Li*, Bailong Xiao*.(2019) Structure and mechanogating of the mammalian tactile channel PIEZO2. Nature, 573:225-229.
7. Zhou H, Luo F, Luo Z, Li D, Liu C, Li X*.(2019) Programming Conventional Electron Microscopes for Solving Ultrahigh-Resolution Structures of Small and Macro-Molecules.Anal Chem.,91(17):10996-11003.
8. Li M, Xia X, Tian Y, Jia Q, Liu X, Lu Y, Li M, Li X*, Chen Z*.(2019)Mechanism of DNA translocation underlying chromatin remodelling by Snf2. Nature, 567(7748):409-413.
9. Zhou H, Luo Z, Li X*.(2019)Using focus ion beam to prepare crystal lamella for electron diffraction.J Struct Biol., 205(3):59-64.
10. Zhao Q, Zhou H, Chi S, Wang Y, Wang J, Geng J, Wu K, Liu W, Zhang T, Dong MQ, Wang J, Li X*, Xiao B*. (2018) Structure and mechanogating mechanism of the Piezo1 channel. Nature, 554(7693):487-492.
11. Mingxu Hu, Hongkun Yu, Kai Gu, Zhao Wang, Huabin Ruan, Kunpeng Wang, Siyuan Ren, Bing Li, Lin Gan, Shizhen Xu, Guangwen Yang*, Yuan Shen*, Xueming Li*, A particle-filter framework for robust cryoEM 3D reconstruction, Nature Methods, 2018, 15, 1083-1089