Contact information

Chunlai Chen Ph.D.

Associate Professor


1999-2003College of Chemistry and Molecular Engineering, Peking University B.S.

2003-2008College of Chemistry and Molecular Engineering, Peking University Ph.D.

2008-2015University of Pennsylvania Postdoc.

2015-2018School of Life Sciences, Tsinghua University Assistant Professor

2018-PresentSchool of Life Sciences, Tsinghua University Associate Professor

Main Reaearch Fields

1) Develop cutting-edge single molecule fluorescence methods.

2) Dynamics and molecular mechanisms of target searching of proteins on DNA.

3) Molecular mechanisms of CRISPR proteins in target searching and cleavage.

Selected Publications

1. Yuan J#, Chen K#, Zhang W, Chen Z*. (2022) Structure of human chromatin-remodelling PBAF complex bound to a nucleosome. Nature, 605(7908):166-171.
2. Wang L#, Chen K#, Chen Z*. (2021) Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome. Nature Comm., 12 (1):4058.
3. Chen M#, Pan H#, Sun L#, Shi P#, Zhang Y, Li L, Huang Y, Chen J, Jiang P, Fang X, Wu C, Chen Z*. (2020) Structure and regulation of human epithelial cell transforming 2 protein. PNAS, 117(2):1027-1035.
4. Ye Y#, Wu H#, Chen K, Clapier CR, Verma N, Zhang W, Deng H, Cairns BR*, Gao N*, Chen Z*. (2019 ) Structure of the RSC complex bound to the nucleosome. Science, 66(6467):838-843.
5. Yan L#, Wu H#, Li X, Gao N*, Chen Z*. (2019) Structures of the ISWI-nucleosome complex reveal a conserved mechanism of chromatin remodeling. Nat. Struct. Mol. Biol., 26(4):258-266.
6. Li M# Xia X#, Tian Y#, Jia Q#, Liu X#, Lu Y, Li M*, Li X*, Chen Z*. (2019) Mechanism of DNA translocation underlying chromatin remodelling by Snf2. Nature, 567(7748):409-413.
7. Liu X#, Li M#, Xia X#, Li X*, Chen Z*. (2017) Mechanism of chromatin remodelling revealed by the Snf2-nucleosome structure Nature,544 (7651):440-445.
8. Yan L#, Wang L#, Tian Y, Xia X, Chen Z*. (2016) Structure and regulation of the chromatin remodeller ISWI. Nature,540(7633):466-469.
9. Xu P#, Li C#, Chen Z, Jiang S, Fan S, Wang J, Dai J, Zhu P*, Chen Z*. (2016) The NuA4 core complex 
acetylates nucleosomal histone H4 through a double recognition mechanism. Mol. Cell., 63 (6):965-75.
10. Xia X#, Liu X#, Li T, Fang, X, Chen Z*. (2016) Structure of chromatin remodeller Swi2/Snf2 in the resting state. Nat. Struct. Mol. Biol., 23(8):722-9