Contact information

Email:suisf@mail.tsinghua.edu.cn

Website

Senfang Sui Ph.D.

Professor | Academician of the Chinese Academy of Sciences

Resume

1964-1970Department of Precision Instrument, Tsinghua University B. S.

1978-1981Department of Engineering Physics, Tsinghua University M. S.

1985-1988Biophysics Institute, Technical University Munich Ph.D.

1989-1991Department of Biological Sciences and Biotechnology, Tsinghua University Associate Professor

1991-PresentSchool of Life Sciences, Tsinghua University Professor

Main Reaearch Fields

Using cryo-electron microscopy (cryo-EM) in combination with biochemical, biophysical and cellular methods, our lab currently focuses on (1) structures, functions and mechanisms of large protein complexes, macromolecular machines and membrane proteins, and (2) molecular mechanisms of membrane trafficking, lipid-protein interactions and membrane-related human diseases.

Selected Publications

    1. C. Mi, L. Zhang, G. Huang, G. Shao, F. Yang, X. You, M.-Q. Dong, S. Sun, and S.-F. Sui, “Structural basis for assembly of TRAPPII complex and specific activation of GTPase Ypt31/32.,” Science Advances, vol. 8, no. 4, p. eabi5603, Jan. 2022.

    2. M. Hu, F. Yang, Y. Huang, X. You, D. Liu, S. Sun, and S.-F. Sui, “Structural insights into the mechanism of human NPC1L1-mediated cholesterol uptake.,” Science Advances, vol. 7, no. 29, Jul. 2021.

    3. Li, M., Ma, J., Li, X.*, and Sui, S.-F.* (2021) In situ cryo-ET structure of phycobilisome-photosystem II supercomplex from red alga. elife. 10.7554/eLife.69635.

    4. Sui, S.-F.* (2021) Structure of Phycobilisomes. Annu Rev Biophys. 50, 53–72.

    5.  Ma J,You X,Sun S,Wang X, Qin S,Sui SF*.(2020)Structural basis of energy transfer in Porphyridium purpureum phycobilisome. Nature, 579(7797):146-151.

    6. Pi X, Zhao S, Wang W, Liu D, Xu C, Han G, Kuang T, Sui SF*, Shen JR*. (2019) The pigment-protein network of a diatom photosystem II-light-harvesting antenna supercomplex. Science,365(6452).

    7. Huang X, Sun S, Wang X, Fan F, Zhou Q, Lu S, Cao Y, Wang QW, Dong MQ, Yao J, Sui SF*.(2019)Mechanistic insights into the SNARE complex disassembly. Sci Adv.,5(4).

    8. Zhang J, Ma J, Liu D, Qin S, Sun S*, Zhao J, Sui SF*. (2017) Structure of phycobilisome from the red alga Griffithsia pacifica. Nature, 551(7678):57-63.

    9. Sun S, Li L, Yang F, Wang X, Fan F, Yang M, Chen C, Li X, Wang HW, Sui SF*. (2017) Cryo-EM structures of the ATP-bound Vps4-E233Q hexamer and its complex with Vta1 at near-atomic resolution. Nat Commun., 8:16064.

    10. Hu Z, Zhou Q, Zhang C, Fan S, Cheng W, Zhao Y, Shao F, Wang HW, Sui SF*, Chai J*. (2015) Structural and Biochemical Basis for Induced Self-propagation of NLRC4. Science, 350(6259):399-404.