Contact information

Email:hongweiwang@tsinghua.edu.cn

Website

Hongwei Wang Ph.D.

Professor | Winner for Tan Jiazhen Life Sciences Innovation Award | Winner for Explore Prize

Resume

1992-1996Department of Biological Sciences and Biotechnology, Tsinghua University B.S.

1996-2001Department of biological Sciences and Biotechnology, Tsinghua University Ph.D.

2001-2006Life Sciences Division, Lawrence Berkeley National Laboratory Postdoc.

2006-2008Life Sciences Division, Lawrence Berkeley National Laboratory Research Scientist

2009-2011Department of Molecular Biophysics and Biochemistry, Yale University Assistant Professor

2010.12-PresentSchool of Life Sciences, Tsinghua University Professor

2016.04-2021.04School of Life Sciences, Tsinghua University Dean

Main Reaearch Fields

Our research group is devoted to elucidating the architecture and mechanism of macromolecular complexes and assemblies with cryo-electron microscopy. More specifically, we are interested in: (1) methodology development for more efficient and high resolution cryo-electron microscopy, (2) the coordination mechanisms of cytoskeleton and membrane systems, and (3) the mechanism and regulations of nucleic acid quality control.

Selected Publications

1. Chen J, Liu N, Huang Y, Wang Y, Sun Y, Wu Q, Li D, Gao S, Wang HW*, Huang N*, Qi X*, Wang XD*. (2021) Structure of PDE3A-SLFN12 complex and structure-based design for a potent apoptosis inducer of tumor cells. Nat. Commun., 12(1):6204.
2. Zheng L, Liu N, Liu Y, Li N, Zhang J, Wang C, Zhu W, Chen Y, Ying D, Xu J, Yang Z, Gao X, Tang J, Wang X, Liang Z, Zou R, Li Y, Gao P, Wei X*, Wang HW*, Peng HL*. (2021) Atomically Thin Bilayer Janus Membranes for Cryo-electron Microscopy. ACS Nano., 15(10):16562-16571.
3. Liu N, Zheng LM, Xu J, Wang J, Hu CX, Lan J, Zhang X, Zhang J, Xu K, Cheng H, Yang Z, Gao X, Wang X, Peng HL*, Chen YN*, Wang HW*. (2021) Reduced graphene oxide membrane as supporting film for high-resolution cryo-EM. Biophysics Reports, 7(3): 227-238. (Cover)
4. Jin W, Wang J, Liu CP, Wang HW*, Xu RM*. (2020) Structural Basis for pri-miRNA Recognition by Drosha. Mol. Cell, 78(3): 423-439.
5. Dai A, Yu L*, Wang HW*. (2019) WHAMM initiates autolysosome tubulation by promoting actin polymerization on autolysosomes. Nat Commun.,10(1):3699.
6. Fan X, Wang J, Zhang X, Yang Z, Zhang JC, Zhao L, Peng HL, Lei J*, Wang HW*.(2019) Single particle cryo-EM reconstruction of 52 kDa streptavidin at 3.2 Angstrom resolution. Nat Commun.,10(1):2386.
7. Wang J, Wang J, Hu M, Wu S, Qi J, Wang G, Han Z, Qi Y, Gao N, Wang HW*, Zhou JM*, Chai J*. (2019) Ligand-triggered allosteric ADP release primes a plant NLR complex. Science, 364(6435). pii: eaav5868.
8. Wang J, Hu M, Wang J, Qi J, Han Z, Wang G, Qi Y, Wang HW*, Zhou JM*, Chai J*. (2019) Reconstitution and structure of a plant NLR resistosome conferring immunity. Science, 364(6435). pii: eaav5870.
9. Liu N, Zhang J, Chen Y,* Liu C, Zhang X, Xu K, Wen J, Luo Z, Chen S, Gao P, Jia K, Liu Z, Peng H*, Wang HW*. (2019) Bioactive Functionalized Monolayer Graphene for High-Resolution Cryo-Electron Microscopy. J Am Chem Soc., 141(9):4016-4025.
10. Liu Z, Wang J, Cheng H, Ke X, Sun L, Zhang QC, Wang HW*. (2018) Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate. Cell, 173(5):1191-1203.