Contact information

Rui Zhou Ph.D.

2017 National Scholarship
2017 Scholarship, Beijing Advanced Innovation Center for Structural Biology
2018 Advanced Innovation Fellow, Beijing Advanced Innovation Center for Structural Biology

Resume

2009-2013Department of Biotechnology, Northwest A&F University B.S.

2013-2018School of Life Sciences, Tsinghua University Ph.D.

2018-PresentSchool of Life Sciences, Tsinghua University Postdoc.

Main Reaearch Fields

Structural and functional studies of Alzheimer's Disease related membrane protein complex:γ-secretase.

Selected Publications

1.Rui Zhou*, Guanghui Yang*, Xuefei Guo, Qiang Zhou, Jianlin Lei, Yigong Shi. Recognition of the amyloid precursor protein by human γ-secretase.Science, 2019, 363(6428):eaaw0930.

2.Guanghui Yang*,Rui Zhou*, Qiang Zhou, Xuefei Guo, Meng Ke, Jianlin Lei, Yigong Shi. Structural basis of Notch recognition by human γ-secretase.Nature, 2019,565(7738):192-197.

3.Rui Zhou*, Guanghui Yang*, Yigong Shi. Dominant negative effect of the loss-of-function γ-secretase mutants on the wild-type enzyme through heterooligomerization.Proceedings of the National Academy of Sciences, 114(48):12731-12736.